P4HB and LCE2D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		P4HB	LCE2D
Description		prolyl 4-hydroxylase subunit beta	late cornified envelope 2D
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Protein-disulfide Reductase Activity Isomerase Activity Thiol Oxidase Activity Enzyme Binding Protein-containing Complex Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Insulin Processing Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Cellular Response To Hypoxia Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Migration	Epidermis Development Keratinization
Pathways		Collagen biosynthesis and modifying enzymes Insulin processing Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly LDL remodeling Interleukin-12 signaling Interleukin-23 signaling	Formation of the cornified envelope
Drugs		Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		54 interacting genes: CD1D CHCHD2 CNNM3 COL10A1 COL1A1 COL1A2 CSNK2A2 CST2 EIF2S1 ENO1 ERN1 ERO1A ERO1B ESR1 FAM20C FEZ1 FNDC3B FZD10 GARIN6 GRN HNRNPD ITGB3 KLHL42 KRTAP12-3 KRTAP13-2 KRTAP4-11 KRTAP5-9 KRTAP6-3 KRTAP9-8 LCE1B LCE2D LCE4A LCN2 LGALS9 LINC00839 LRFN4 NECTIN2 NOL4 NTM ODF1 OGT P4HA2 P4HA3 PDE4B PLCXD3 PRNP PTN SUMO2 TG TGFB1 UBQLN1 VWF YWHAG ZNF69	72 interacting genes: ADAMTSL4 CYSRT1 EFEMP2 GLRX3 GRN GUCD1 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3C LCE3D LCE4A LCE5A NBPF19 NCALD NOTCH2NLA NR4A3 NUFIP2 OTX1 P4HB PLA2G10 PLSCR1 RGS20 RNF4 SLC39A7 SMCP SPRY1 SPRY2 SUMO1P1 TRIM42 TSPAN4 VASN VWC2
Entrez ID		5034	353141
HPRD ID		07181	17261
Ensembl ID		ENSG00000185624	ENSG00000187223
Uniprot IDs		A0A024R8S5 P07237	Q5TA82
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S 7ZSC 8EOJ 8GDY
Enriched GO Terms of Interacting Partners?		Protease Binding Identical Protein Binding Endoplasmic Reticulum Lumen Collagen Type I Trimer Intermediate Filament Cellular Response To Oxygen-containing Compound Protein Binding Extracellular Space Collagen Fibril Organization Cellular Response To Glucose Stimulus Response To Amino Acid Response To Monosaccharide Tissue Development Response To Kainic Acid Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Keratinization Cellular Response To Carbohydrate Stimulus Procollagen-proline 4-dioxygenase Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Response To Tumor Cell Extracellular Matrix Organization Extracellular Structure Organization Response To Oxidative Stress Thiol Oxidase Activity Response To Carbohydrate Intracellular Glucose Homeostasis Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Proteolysis Odontoblast Differentiation Biomineral Tissue Development Keratin Filament Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Leukocyte Mediated Cytotoxicity Cellular Response To Growth Factor Stimulus Negative Regulation Of Innate Immune Response Regulation Of Monoatomic Ion Transmembrane Transport Response To Xenobiotic Stimulus Fibrillar Collagen Trimer Positive Regulation Of Axon Regeneration Regulation Of Endothelial Cell Migration Regulation Of Lymphocyte Mediated Immunity Carbohydrate Homeostasis Response To Estradiol Glucose Homeostasis Negative Regulation Of Translational Initiation Negative Regulation Of Leukocyte Activation Regulation Of Innate Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Growth Factor Positive Regulation Of Proteolysis	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Protein Binding Cytosol Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Microtubule End Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?