CCL3L3 and CCR5

Number of citations of the paper that reports this interaction (PubMedID 11734558)
0

Data Source:
HPRD (in vitro, in vivo)

		CCL3L3	CCR5
Description		C-C motif chemokine ligand 3 like 3	C-C motif chemokine receptor 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding	Virus Receptor Activity Actin Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Apoptotic Process Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Symbiont Entry Into Host Cell Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Macrophage Apoptotic Process
Pathways		Chemokine receptors bind chemokines Interleukin-10 signaling	Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs			Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471
Diseases
GWAS		Body mass index ( 26426971)	Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		6 interacting genes: ACKR2 CCR5 MGST2 SGTB SLC41A3 TMEM179B	43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK
Entrez ID		414062	1234
HPRD ID		14426	03223
Ensembl ID		ENSG00000276085	ENSG00000160791
Uniprot IDs		P16619	P51681 Q38L21
PDB IDs			2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET 7F1Q 7F1R 7F1S 7NJZ 7NW3 7O7F 8AS2 8AS3
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding TRC Complex Mitochondrial Magnesium Ion Transmembrane Transport Magnesium:sodium Antiporter Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Decoy Activity Calcium-mediated Signaling Leukotriene-C4 Synthase Activity Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Locomotion Dendritic Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Macrophage Apoptotic Process External Side Of Plasma Membrane Plasma Membrane Chemotaxis Membrane Glutathione Biosynthetic Process Glutathione Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Monoatomic Cation Transmembrane Transporter Activity Leukotriene Biosynthetic Process G Protein-coupled Receptor Activity Negative Regulation Of Myeloid Cell Apoptotic Process Glutathione Peroxidase Activity Cytokine-mediated Signaling Pathway Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Peptide Biosynthetic Process Response To Cholesterol Protein Heterooligomerization Glutathione Transferase Activity Protein Targeting To ER Leukotriene Metabolic Process Regulation Of Myeloid Cell Apoptotic Process Establishment Of Protein Localization To Endoplasmic Reticulum	Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Chemokine Activity G Protein-coupled Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Antimicrobial Humoral Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Humoral Immune Response Regulation Of Cell Motility Signal Transduction Regulation Of Locomotion Granulocyte Chemotaxis Leukocyte Migration Chemotaxis Granulocyte Migration Defense Response Cell Migration Leukocyte Chemotaxis Inflammatory Response Locomotion Response To Other Organism Response To External Biotic Stimulus Cell Motility Regulation Of Lymphocyte Chemotaxis Myeloid Leukocyte Migration Defense Response To Symbiont Positive Regulation Of Natural Killer Cell Chemotaxis Defense Response To Other Organism Guanyl Nucleotide Binding CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Non-membrane Spanning Protein Tyrosine Kinase Activity G-protein Beta/gamma-subunit Complex Binding Protein Kinase Activity Interleukin-9-mediated Signaling Pathway
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