TPST1 and CCR1

Number of citations of the paper that reports this interaction (PubMedID 17558413)
0

Data Source:
HPRD (in vitro)

		TPST1	CCR1
Description		tyrosylprotein sulfotransferase 1	C-C motif chemokine receptor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein-tyrosine Sulfotransferase Activity Transferase Activity Protein Homodimerization Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Post-translational Protein Modification 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process	Dendritic Cell Chemotaxis Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Canonical NF-kappaB Signal Transduction Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Cytosolic sulfonation of small molecules Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Defective F8 sulfation at Y1699	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Gout ( 22179738)	Arthritis (juvenile idiopathic) ( 33106285) Aspartate aminotransferase levels ( 33547301) Behcet's disease ( 23291587) Celiac disease ( 18311140 20190752 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Myocardial infarction ( 33532862) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		9 interacting genes: CCR1 CCR8 CMKLR1 CMKLR2 GOLPH3 GOLPH3L GP1BA SELPLG TMEM132D	30 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 SNCA STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2
Entrez ID		8460	1230
HPRD ID		07216	03101
Ensembl ID		ENSG00000169902	ENSG00000163823
Uniprot IDs		O60507	P32246 Q5U003
PDB IDs		5WRI 5WRJ	7VL8 7VL9 7VLA
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity Adipokinetic Hormone Binding Adipokinetic Hormone Receptor Activity Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Chemokine-mediated Signaling Pathway Golgi Cisterna G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration C-C Chemokine Binding C-C Chemokine Receptor Activity Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Phosphatidylinositol-4-phosphate Binding Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Leukocyte Cell-cell Adhesion Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Chemotaxis Golgi Cisterna Membrane External Side Of Plasma Membrane Locomotion Cell Migration Positive Regulation Of Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding Positive Regulation Of Leukocyte Chemotaxis Chemokine (C-C Motif) Ligand 7 Binding Cellular Response To Cytokine Stimulus Leukocyte Adhesive Activation Asymmetric Golgi Ribbon Formation Post-Golgi Vesicle-mediated Transport Cell Motility Cell Adhesion Molecule Production Cellular Response To Rapamycin Golgi Organization Plasma Membrane Protein Retention In Golgi Apparatus Vesicle-mediated Transport To The Plasma Membrane Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Response To Peptide Positive Regulation Of Chemotaxis Response To Cytokine	CCR Chemokine Receptor Binding Chemokine Activity Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Eosinophil Migration Antimicrobial Humoral Response Cytokine-mediated Signaling Pathway CCR1 Chemokine Receptor Binding Humoral Immune Response Chemotaxis Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Inflammatory Response Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cell Migration Response To External Biotic Stimulus Cell-cell Signaling Defense Response To Symbiont Regulation Of Cell Motility Monocyte Chemotaxis Defense Response Signaling Defense Response To Other Organism Response To Stress Cell Communication Response To Other Organism Calcium Ion Homeostasis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Calcium Ion Transport Immune Response Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Immune System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis
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