TPST1

Description		tyrosylprotein sulfotransferase 1
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane
	Molecular Function	Protein-tyrosine Sulfotransferase Activity Transferase Activity Protein Homodimerization Activity
	Biological Process	Post-translational Protein Modification 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Pathways		Cytosolic sulfonation of small molecules Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Defective F8 sulfation at Y1699
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Gout ( 22179738)
Interacting Genes		9 interacting genes: CCR1 CCR8 CMKLR1 CMKLR2 GOLPH3 GOLPH3L GP1BA SELPLG TMEM132D
Entrez ID		8460
HPRD ID		07216
Ensembl ID		ENSG00000169902
Uniprot IDs		O60507
PDB IDs		5WRI 5WRJ
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity Adipokinetic Hormone Binding Adipokinetic Hormone Receptor Activity Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Chemokine-mediated Signaling Pathway Golgi Cisterna G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration C-C Chemokine Binding C-C Chemokine Receptor Activity Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Phosphatidylinositol-4-phosphate Binding Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Leukocyte Cell-cell Adhesion Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Chemotaxis Golgi Cisterna Membrane External Side Of Plasma Membrane Locomotion Cell Migration Positive Regulation Of Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding Positive Regulation Of Leukocyte Chemotaxis Chemokine (C-C Motif) Ligand 7 Binding Cellular Response To Cytokine Stimulus Leukocyte Adhesive Activation Asymmetric Golgi Ribbon Formation Post-Golgi Vesicle-mediated Transport Cell Motility Cell Adhesion Molecule Production Cellular Response To Rapamycin Golgi Organization Plasma Membrane Protein Retention In Golgi Apparatus Vesicle-mediated Transport To The Plasma Membrane Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Response To Peptide Positive Regulation Of Chemotaxis Response To Cytokine
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