TPST1 and CMKLR1

Number of citations of the paper that reports this interaction (PubMedID 17558413)
0

Data Source:
HPRD (in vitro)

		TPST1	CMKLR1
Description		tyrosylprotein sulfotransferase 1	chemerin chemokine-like receptor 1
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane	Plasma Membrane Membrane
	Molecular Function	Protein-tyrosine Sulfotransferase Activity Transferase Activity Protein Homodimerization Activity	Complement Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Signaling Receptor Activity Adipokinetic Hormone Receptor Activity Adipokinetic Hormone Binding
	Biological Process	Post-translational Protein Modification 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process	Skeletal System Development Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Immune Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Macrophage Chemotaxis Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-12 Production Positive Regulation Of Fat Cell Differentiation Regulation Of Calcium-mediated Signaling Chemokine-mediated Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Cytosolic sulfonation of small molecules Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Defective F8 sulfation at Y1699	Class A/1 (Rhodopsin-like receptors)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Gout ( 22179738)	Acne (severe) ( 24927181) Bipolar disorder ( 22688191) Erectile dysfunction and prostate cancer treatment ( 20932654) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Protein level change in low calorie diet obesity intervention ( 29234017) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 21483023) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		9 interacting genes: CCR1 CCR8 CMKLR1 CMKLR2 GOLPH3 GOLPH3L GP1BA SELPLG TMEM132D	2 interacting genes: TPST1 TPST2
Entrez ID		8460	1240
HPRD ID		07216	03829
Ensembl ID		ENSG00000169902	ENSG00000174600
Uniprot IDs		O60507	Q99788
PDB IDs		5WRI 5WRJ	7YKD 8SG1 8ZJG 9L3W
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity Adipokinetic Hormone Binding Adipokinetic Hormone Receptor Activity Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Chemokine-mediated Signaling Pathway Golgi Cisterna G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration C-C Chemokine Binding C-C Chemokine Receptor Activity Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Phosphatidylinositol-4-phosphate Binding Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Leukocyte Cell-cell Adhesion Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Chemotaxis Golgi Cisterna Membrane External Side Of Plasma Membrane Locomotion Cell Migration Positive Regulation Of Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding Positive Regulation Of Leukocyte Chemotaxis Chemokine (C-C Motif) Ligand 7 Binding Cellular Response To Cytokine Stimulus Leukocyte Adhesive Activation Asymmetric Golgi Ribbon Formation Post-Golgi Vesicle-mediated Transport Cell Motility Cell Adhesion Molecule Production Cellular Response To Rapamycin Golgi Organization Plasma Membrane Protein Retention In Golgi Apparatus Vesicle-mediated Transport To The Plasma Membrane Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Response To Peptide Positive Regulation Of Chemotaxis Response To Cytokine	Protein-tyrosine Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Golgi Lumen Peptidyl-tyrosine Sulfation Trans-Golgi Network Sulfur Compound Metabolic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Metabolic Process Protein Sulfation Nucleotide Metabolic Process Prevention Of Polyspermy Purine-containing Compound Metabolic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Fertilization Golgi Membrane Protein Homodimerization Activity Organic Acid Metabolic Process Carbohydrate Derivative Metabolic Process Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Sulfation Plasma Membrane Fusion Organophosphate Metabolic Process Phosphate-containing Compound Metabolic Process Golgi Apparatus Small Molecule Metabolic Process Negative Regulation Of Reproductive Process Protein Modification Process Transferase Activity Plasma Membrane Organization Membrane Fusion Regulation Of Reproductive Process Nucleobase-containing Compound Metabolic Process Protein Metabolic Process
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