JDP2 and HDAC5

Number of citations of the paper that reports this interaction (PubMedID 22989952)
45

Data Source:
BioGRID (pull down)

		JDP2	HDAC5
Description		Jun dimerization protein 2	histone deacetylase 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Homodimerization Activity Histone Deacetylase Binding Leucine Zipper Domain Binding Protein Heterodimerization Activity Histone Chaperone Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity Transcription Corepressor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity Protein Lysine Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Inflammatory Response Response To Xenobiotic Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Epigenetic Regulation Of Gene Expression B Cell Activation Response To Cocaine Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		Pseudoephedrine	Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Appendicular lean mass ( 33097823) Basal cell carcinoma ( 31174203 33549134) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 24076602) Obesity-related traits ( 23251661) Periodontal microbiota ( 22699663)	Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 31043756 33263727 34002096) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) Mean platelet volume ( 32888494)
Interacting Genes		22 interacting genes: ATF2 ATF4 CREB5 CREBBP DDIT3 EP300 GTF2H1 HDAC1 HDAC4 HDAC5 HDAC6 IRF2BP1 JUN JUNB JUND KAT2B MAPK14 MAPK8 MAPK9 PGR SNW1 TP53	60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE ZBTB16
Entrez ID		122953	10014
HPRD ID		16360	09246
Ensembl ID		ENSG00000140044	ENSG00000108840
Uniprot IDs		Q8WYK2	Q9UQL6
PDB IDs			5UWI 8Q9P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Rhythmic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Primary Metabolic Process Nucleus Nucleoplasm Regulation Of Macromolecule Metabolic Process Histone Deacetylase Binding Histone Deacetylase Activity, Hydrolytic Mechanism Response To Stress RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Enzyme Binding Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Protein Lysine Deacetylase Activity N-terminal Peptidyl-lysine Acetylation DNA-binding Transcription Factor Binding Intracellular Signaling Cassette Chromatin Binding Response To Nutrient Levels Histone Deacetylase Activity Positive Regulation Of Gene Expression	Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Binding Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Transcription Coregulator Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Nucleocytoplasmic Transport Sequence-specific Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Histone Deacetylase Complex Regulation Of MiRNA Transcription Regulation Of Nucleocytoplasmic Transport
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