SOCS4 and VWF

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SOCS4	VWF
Gene Name		suppressor of cytokine signaling 4	von Willebrand factor
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Extracellular Region Proteinaceous Extracellular Matrix Endoplasmic Reticulum External Side Of Plasma Membrane Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity	Glycoprotein Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein Homodimerization Activity Protein N-terminus Binding Chaperone Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of JAK-STAT Cascade	Liver Development Placenta Development Platelet Degranulation Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Response To Wounding Platelet Activation Extracellular Matrix Organization Cell-substrate Adhesion Protein Homooligomerization
Pathways			Platelet Adhesion to exposed collagen p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Intrinsic Pathway GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Antihemophilic Factor
Diseases
GWAS			Coagulation factor levels ( 23267103) Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		5 interactors: EGFR MDFIC NR4A1 SPRY1 VWF	16 interactors: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 F8 FURIN GP1BA HSPA5 ITGA2B MAP3K3 RAC1 SOCS4 TNFRSF11B ZNF512B
Entrez ID		122809	7450
HPRD ID		18084	01906
Ensembl ID		ENSG00000180008	ENSG00000110799
Uniprot IDs		Q5H9R6 Q8WXH5	P04275
PDB IDs		2IZV	1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4DMU
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Alkanesulfonate Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Phosphatidylinositol-mediated Signaling Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Liver Development Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Protein Import Into Nucleus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Steroid Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Placenta Development Response To Fibroblast Growth Factor Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Activation Of Phospholipase A2 Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Positive Regulation Of Phospholipase A2 Activity Lung Development Respiratory Tube Development Organ Development Response To Cobalamin Response To UV-A Regulation Of Intracellular Protein Transport Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Response To Stress Vesicle-mediated Transport Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Cell Communication Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Response To Organic Substance Signal Transduction Collagen Catabolic Process Cellular Response To Stimulus Platelet Degranulation Secretion By Cell Response To Stimulus Collagen Metabolic Process Signaling Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Positive Regulation Of Leukocyte Migration Multicellular Organismal Metabolic Process Regulation Of Cell Migration Extracellular Matrix Disassembly Regulation Of Cell Motility Secretion Regulation Of Signaling Blood Coagulation, Intrinsic Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Leukocyte Migration Regulation Of Locomotion Exocytosis Cellular Localization Regulation Of Cellular Component Movement Anatomical Structure Arrangement Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction
Tagcloud ?		abovementioned activators exceptions expressions glucocorticosteroids jak jak1 jak3 jaks leukocytes nephrotic ns socs1 socs2 socs3 socs5 srns ssns stat stat2 stat6 stats steroid steroids suppressors transducers tyk2 unfavorable	afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite
Tagcloud (Difference) ?		abovementioned activators exceptions expressions glucocorticosteroids jak jak1 jak3 jaks leukocytes nephrotic ns socs1 socs2 socs3 socs5 srns ssns stat stat2 stat6 stats steroid steroids suppressors transducers tyk2 unfavorable	afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite
Tagcloud (Intersection) ?