SOCS4 and LDHAL6B

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		SOCS4	LDHAL6B
Description		suppressor of cytokine signaling 4	lactate dehydrogenase A like 6B
Image			No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Oxidoreductase Complex
	Molecular Function	Protein Binding	Catalytic Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction	Lactate Metabolic Process Carboxylic Acid Metabolic Process Pyruvate Catabolic Process
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Pyruvate metabolism
Drugs			NADH
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817)
Interacting Genes		11 interacting genes: CNMD EGFR LDHAL6B MDFIC NR4A1 PALS1 PLPP6 SPRY1 TEKT4 TNK2 VWF	6 interacting genes: APPL2 HSH2D PRMT5 PRMT6 SOCS4 SUV39H1
Entrez ID		122809	92483
HPRD ID		18084	13981
Ensembl ID		ENSG00000180008	ENSG00000171989
Uniprot IDs		Q8WXH5	A0A140VJM9 Q9BYZ2
PDB IDs		2IZV
Enriched GO Terms of Interacting Partners?			Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Methyltransferase Activity Methylation Negative Regulation Of Metabolic Process Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Peptidyl-arginine N-methylation Dense Core Granule Membrane Negative Regulation Of Type 2 Mitophagy Histone H3R2 Methyltransferase Activity Positive Regulation Of Macropinocytosis ENoSc Complex Negative Regulation Of Macromolecule Metabolic Process Circadian Rhythm Protein-arginine Omega-N Symmetric Methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Early Phagosome Membrane Cold Acclimation Regulation Of Multicellular Organismal Development Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling RDNA Heterochromatin Positive Regulation Of Dopamine Receptor Signaling Pathway Peptidyl-arginine Methylation Protein Retention In Golgi Apparatus Protein-arginine Omega-N Monomethyltransferase Activity Macropinosome Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway RDNA Heterochromatin Formation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Positive Regulation Of Pinocytosis Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose Chromatin Organization Regulation Of Cell Development Adiponectin-activated Signaling Pathway Negative Regulation Of Mitochondrial Depolarization Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Histone H3K9 Methyltransferase Activity Golgi Ribbon Formation Endothelial Cell Activation Diet Induced Thermogenesis Nuclear Lamina
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