SOCS4 and PALS1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		SOCS4	PALS1
Description		suppressor of cytokine signaling 4	protein associated with LIN7 1, MAGUK p55 family member
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GO Annotations	Cellular Component		Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Endomembrane System Membrane Apical Plasma Membrane Axon Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Myelin Sheath Adaxonal Region Cell Projection Perikaryon Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction	Morphogenesis Of An Epithelial Sheet Plasma Membrane Organization Intracellular Protein Localization Gene Expression Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Generation Of Neurons Protein Localization To Plasma Membrane
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Tight junction interactions SARS-CoV-1 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817)
Interacting Genes		11 interacting genes: CNMD EGFR LDHAL6B MDFIC NR4A1 PALS1 PLPP6 SPRY1 TEKT4 TNK2 VWF	14 interacting genes: ARF6 CRB3 DLGAP4 FTCD GPRASP3 LIN7A MPP4 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2
Entrez ID		122809	64398
HPRD ID		18084	09508
Ensembl ID		ENSG00000180008	ENSG00000072415
Uniprot IDs		Q8WXH5	Q8N3R9
PDB IDs		2IZV	1Y76 3UIT 4UU5 4UU6 4WSI 7M4R 7NTJ 7NTK 7QCS
Enriched GO Terms of Interacting Partners?			Apical Part Of Cell Regulation Of Cell Junction Assembly Regulation Of Synapse Organization Bicellular Tight Junction Regulation Of Synapse Assembly Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Thioesterase Binding Cell Junction Organization Regulation Of Cellular Component Organization Apical Junction Complex Anchoring Junction Cell Cortex Cell-cell Junction Organization Tight Junction Cell Division Cell Junction Positive Regulation Of Cellular Component Biogenesis Erythrocyte Apoptotic Process TORC2 Complex Disassembly Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Extracellular Exosome Regulation Of Dendritic Spine Development Glutamatergic Synapse Plasma Membrane TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide Signaling Adaptor Activity Protein Localization To Cleavage Furrow Neuroblast Division In Subventricular Zone L27 Domain Binding Subapical Complex
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