SOCS4 and MDFIC

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SOCS4	MDFIC
Description		suppressor of cytokine signaling 4	MyoD family inhibitor domain containing
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GO Annotations	Cellular Component		Extracellular Region Nucleus Nucleolus Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Cyclin Binding Tat Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction	Regulation Of Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of JNK Cascade Positive Regulation Of Viral Transcription
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817)	Adventurousness ( 30643258) Body mass index ( 26426971 28892062) Clozapine-induced cytotoxicity ( 25656473) Drug experimentation measurement ( 30718321) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Number of sexual partners ( 30643258) Obesity ( 23818313) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Smoking status (ever vs never smokers) ( 30643258) Tonsillectomy ( 27182965 28928442)
Interacting Genes		11 interacting genes: CNMD EGFR LDHAL6B MDFIC NR4A1 PALS1 PLPP6 SPRY1 TEKT4 TNK2 VWF	4 interacting genes: CCNT1 CDK9 RPS6KA5 SOCS4
Entrez ID		122809	29969
HPRD ID		18084	17103
Ensembl ID		ENSG00000180008	ENSG00000135272
Uniprot IDs		Q8WXH5	Q9P1T7
PDB IDs		2IZV	8YFC 8YFG 8ZU3
Enriched GO Terms of Interacting Partners?			P-TEFb Complex 7SK SnRNA Binding Cyclin/CDK Positive Transcription Elongation Factor Complex SnRNA Binding Host-mediated Activation Of Viral Transcription Host-mediated Perturbation Of Viral Transcription Host-mediated Activation Of Viral Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Host-mediated Perturbation Of Viral Process Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Symbiont Process Histone H2AS1 Kinase Activity Modulation Of Process Of Another Organism Histone H3S28 Kinase Activity Positive Regulation Of Protein Localization To Chromatin Histone H3S10 Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Transcription Pausing By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Metabolic Process Transcription Elongation-coupled Chromatin Remodeling Transcription By RNA Polymerase II Regulation Of Protein Localization To Chromatin Transcription Elongation Factor Activity Positive Regulation Of CREB Transcription Factor Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of MRNA 3'-end Processing Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Protein Phosphorylation Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Phosphorylation Negative Regulation Of Protein Tyrosine Kinase Activity Protein Modification Process Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytokine-mediated Signaling Pathway DNA-templated Transcription Regulation Of Phosphorylation Protein Kinase Binding Positive Regulation Of RNA Metabolic Process
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