SOCS4 and MDFIC

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SOCS4	MDFIC
Gene Name		suppressor of cytokine signaling 4	MyoD family inhibitor domain containing
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus
	Molecular Function	Protein Kinase Inhibitor Activity	Protein Binding Transcription Factor Binding Cyclin Binding Tat Protein Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of JAK-STAT Cascade	Transcription, DNA-templated Activation Of JUN Kinase Activity Viral Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription
Pathways
Drugs
Diseases
GWAS			Obesity ( 23818313)
Protein-Protein Interactions		5 interactors: EGFR MDFIC NR4A1 SPRY1 VWF	4 interactors: CCNT1 CDK9 RPS6KA5 SOCS4
Entrez ID		122809	29969
HPRD ID		18084	17103
Ensembl ID		ENSG00000180008	ENSG00000135272
Uniprot IDs		Q5H9R6 Q8WXH5	Q9P1T7
PDB IDs		2IZV
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Alkanesulfonate Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Phosphatidylinositol-mediated Signaling Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Liver Development Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Protein Import Into Nucleus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Steroid Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Placenta Development Response To Fibroblast Growth Factor Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Activation Of Phospholipase A2 Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Positive Regulation Of Phospholipase A2 Activity Lung Development Respiratory Tube Development Organ Development Response To Cobalamin Response To UV-A Regulation Of Intracellular Protein Transport Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Response To Growth Factor DNA-templated Transcription, Elongation Regulation Of Protein Metabolic Process Response To Cytokine Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Histone H2A-S1 Phosphorylation Replication Fork Arrest Regulation Of Histone Modification Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Phosphorylation Response To Transforming Growth Factor Beta Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process DNA-templated Transcription, Initiation Histone H3-S10 Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorylation Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Histone Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H3-S28 Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Cellular Ketone Metabolic Process
Tagcloud ?		abovementioned activators exceptions expressions glucocorticosteroids jak jak1 jak3 jaks leukocytes nephrotic ns socs1 socs2 socs3 socs5 srns ssns stat stat2 stat6 stats steroid steroids suppressors transducers tyk2 unfavorable
Tagcloud (Difference) ?		abovementioned activators exceptions expressions glucocorticosteroids jak jak1 jak3 jaks leukocytes nephrotic ns socs1 socs2 socs3 socs5 srns ssns stat stat2 stat6 stats steroid steroids suppressors transducers tyk2 unfavorable
Tagcloud (Intersection) ?