FRMD6 and TSC22D4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		FRMD6	TSC22D4
Gene Name		FERM domain containing 6	TSC22 domain family, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Apical Junction Complex	Nucleus Cytoplasm
	Molecular Function		Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Apical Constriction Regulation Of Actin Filament-based Process Cellular Protein Localization	Transcription, DNA-templated Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Anticoagulant levels ( 22216198) Brain structure ( 20171287) Hippocampal atrophy ( 19668339) Total ventricular volume ( 21116278)
Protein-Protein Interactions		19 interactors: BLZF1 COX6B2 DNAJA3 EXOC5 GMCL1 HMBOX1 IKZF1 JMJD6 LOC727751 LZTS2 MED4 MID2 MLH1 RASSF8 SSX2IP SUV39H1 TSC22D4 WDR7 YWHAB	53 interactors: ABLIM1 AES AIFM1 APIP BLZF1 BZRAP1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FRMD6 FXR2 GNB2L1 GOLGA2 GORASP2 KEAP1 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 SACS SAT1 SMAD3 SYT17 TEX11 TSC22D1 UBLCP1 ZBTB24 ZMYND10 ZNF580
Entrez ID		122786	81628
HPRD ID		12646	18231
Ensembl ID		ENSG00000139926	ENSG00000166925
Uniprot IDs		Q96NE9	A8MWR6 Q9Y3Q8
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Spindle Midzone Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune System Development Cellular Localization Organelle Organization Regulation Of Gene Expression T Cell Differentiation Lymphocyte Activation Leukocyte Activation Immune System Process Lymphocyte Differentiation Positive Regulation Of Neutrophil Differentiation Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Meiotic Metaphase I Plate Congression Meiotic Spindle Midzone Assembly Hemopoiesis T Cell Aggregation T Cell Activation Lymphocyte Aggregation T Cell Differentiation In Thymus Leukocyte Aggregation Cell Activation Negative Regulation Of Mitotic Recombination Leukocyte Cell-cell Adhesion Spindle Assembly Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Differentiation Post-Golgi Vesicle-mediated Transport Gene Expression Regulation Of Metabolic Process Establishment Of Localization In Cell Cell Cycle Developmental Process Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Membrane Organization Regulation Of Cellular Process	Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Process Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Energy Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Glycolytic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		adni apoc1 apoe bin1 convergent corroborated cr1 employing endophenotypes formally fto genetics grin2b gwas initiative magi2 multidimensional neuroimaging nominated omics phenotypes picalm replicated scope sets synthesize tomm40 trajectory warranting	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Difference) ?		adni apoc1 apoe bin1 convergent corroborated cr1 employing endophenotypes formally fto genetics grin2b gwas initiative magi2 multidimensional neuroimaging nominated omics phenotypes picalm replicated scope sets synthesize tomm40 trajectory warranting	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Intersection) ?