FRMD6 and MED4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FRMD6	MED4
Gene Name		FERM domain containing 6	mediator complex subunit 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Apical Junction Complex	Nucleus Nucleoplasm Membrane Mediator Complex
	Molecular Function		RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Apical Constriction Regulation Of Actin Filament-based Process Cellular Protein Localization	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Anticoagulant levels ( 22216198) Brain structure ( 20171287) Hippocampal atrophy ( 19668339) Total ventricular volume ( 21116278)
Protein-Protein Interactions		19 interactors: BLZF1 COX6B2 DNAJA3 EXOC5 GMCL1 HMBOX1 IKZF1 JMJD6 LOC727751 LZTS2 MED4 MID2 MLH1 RASSF8 SSX2IP SUV39H1 TSC22D4 WDR7 YWHAB	36 interactors: AES AMOT AP2M1 ATF7IP C1orf216 CCDC101 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 IFT20 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED13 MED25 MED30 MED9 NDC80 NDE1 PCBD2 PUM2 SDCBP SMARCD1 SMARCE1 SSX3 TNFAIP8 TXLNA USHBP1 WDTC1
Entrez ID		122786	29079
HPRD ID		12646	16145
Ensembl ID		ENSG00000139926	ENSG00000136146
Uniprot IDs		Q96NE9	Q9NPJ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Spindle Midzone Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune System Development Cellular Localization Organelle Organization Regulation Of Gene Expression T Cell Differentiation Lymphocyte Activation Leukocyte Activation Immune System Process Lymphocyte Differentiation Positive Regulation Of Neutrophil Differentiation Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Meiotic Metaphase I Plate Congression Meiotic Spindle Midzone Assembly Hemopoiesis T Cell Aggregation T Cell Activation Lymphocyte Aggregation T Cell Differentiation In Thymus Leukocyte Aggregation Cell Activation Negative Regulation Of Mitotic Recombination Leukocyte Cell-cell Adhesion Spindle Assembly Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Differentiation Post-Golgi Vesicle-mediated Transport Gene Expression Regulation Of Metabolic Process Establishment Of Localization In Cell Cell Cycle Developmental Process Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Membrane Organization Regulation Of Cellular Process	Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleosome Disassembly Cellular Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Establishment Of Cell Polarity Cellular Localization Cellular Nitrogen Compound Metabolic Process Mitotic Nuclear Division Centrosome Localization Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Establishment Of Mitotic Spindle Orientation Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Mediator Complex Assembly Opsin Transport Regulation Of Cellular Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nitrogen Compound Metabolic Process Chromosome Organization Establishment Or Maintenance Of Cell Polarity Chromatin Organization Cell Division Protein Localization Negative Regulation Of Transcription, DNA-templated Movement Of Cell Or Subcellular Component Spindle Localization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Microtubule-based Process Pteridine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of RNA Biosynthetic Process
Tagcloud ?		adni apoc1 apoe bin1 convergent corroborated cr1 employing endophenotypes formally fto genetics grin2b gwas initiative magi2 multidimensional neuroimaging nominated omics phenotypes picalm replicated scope sets synthesize tomm40 trajectory warranting
Tagcloud (Difference) ?		adni apoc1 apoe bin1 convergent corroborated cr1 employing endophenotypes formally fto genetics grin2b gwas initiative magi2 multidimensional neuroimaging nominated omics phenotypes picalm replicated scope sets synthesize tomm40 trajectory warranting
Tagcloud (Intersection) ?