DNAJC6 and AP2A2

Number of citations: 0 (PubMedID 11470803)
Data Source: HPRD (in vitro)

		DNAJC6	AP2A2
Name		DnaJ heat shock protein family (Hsp40) member C6	adaptor related protein complex 2 subunit alpha 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Synapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Presynapse Postsynapse Ficolin-1-rich Granule Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding Clathrin Binding Heat Shock Protein Binding Clathrin Heavy Chain Binding	Protein Binding Lipid Binding Kinase Binding Protein Kinase Binding Protein Domain Specific Binding Clathrin Adaptor Activity Disordered Domain Specific Binding
	Biological Process	Synaptic Vesicle Uncoating Synaptic Vesicle Recycling Intracellular Transport Clathrin Coat Disassembly Clathrin-dependent Endocytosis Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
GWAS		Anticoagulant levels ( 22216198 ) Idiopathic osteonecrosis of the femoral head ( 28000841 )	Adult asthma ( 27611488 ) Alzheimer's disease ( 30636644 ) Alzheimer's disease (late onset) ( 24162737 ) Asthma ( 31959851 ) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909 ) Nicotine withdrawal ( 29532581 ) Nicotine withdrawal symptom count ( 29532581 )
Novel Interactors		None recorded	4 novel interactors: ILK KCNQ1DN LRPPRC ZPR1
Interacting Genes		3 interacting genes: AP2A2 BAG2 CLTC	18 interacting genes: AMPH ANXA1 AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC
Entrez ID		9829	161
HPRD ID		16326	06256
Ensembl ID		ENSG00000116675	ENSG00000183020
Uniprot IDs		O75061	O94973
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Endolysosome Membrane Disordered Domain Specific Binding Clathrin-coated Endocytic Vesicle Clathrin-dependent Endocytosis Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Clathrin-coated Pit Receptor-mediated Endocytosis Dendritic Microtubule Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Trans-Golgi Network Vesicle Vesicle Uncoating Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin Complex Clathrin Coat Clathrin Coat Of Coated Pit Clathrin Light Chain Binding Clathrin Coat Disassembly Amyloid-beta Clearance By Transcytosis Clathrin Adaptor Complex AP-2 Adaptor Complex Endocytosis Protein Kinase Binding Transferrin Transport Adenyl-nucleotide Exchange Factor Activity Intracellular Protein Transport Mitotic Spindle Microtubule Clathrin Adaptor Activity Transcytosis Ubiquitin-specific Protease Binding Clathrin Coat Assembly Import Into Cell Low-density Lipoprotein Particle Receptor Binding Amyloid-beta Clearance Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Membrane Coat Negative Regulation Of Protein Localization To Plasma Membrane Protein Folding Chaperone Complex Protein Depolymerization Synaptic Vesicle Endocytosis Cytoplasmic Vesicle Presynaptic Endocytosis Regulation Of Mitotic Spindle Organization Iron Ion Transport Tau Protein Binding Ficolin-1-rich Granule Membrane Regulation Of Protein Processing Regulation Of Protein Maturation	Clathrin-coated Pit Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Receptor-mediated Endocytosis Phospholipid Binding Clathrin Coat Assembly Extrinsic Component Of Presynaptic Endocytic Zone Membrane Cytoplasmic Vesicle Vesicle-mediated Transport In Synapse Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptic Vesicle Regulation Of Endocytosis Early Endosome Clathrin-coated Vesicle Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Clathrin-dependent Endocytosis Synapse Regulation Of Receptor-mediated Endocytosis Cellular Response To Growth Factor Stimulus Endosome Postsynaptic Neurotransmitter Receptor Internalization Response To Growth Factor Plasma Membrane Postsynaptic Endocytic Zone Cytoplasmic Vesicle Membrane Intracellular Transport Clathrin Heavy Chain Binding Vesicle Regulation Of Transport AP-2 Adaptor Complex Organelle Organization Presynapse Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Clathrin Adaptor Activity Regulation Of Multicellular Organismal Development Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Cellular Component Organization Cellular Localization Negative Regulation Of Blood Circulation Regulation Of Developmental Process Insulin Receptor Binding Membrane Regulation Of Cellular Component Organization Positive Regulation Of Transport Membrane Coat Chemical Synaptic Transmission