TPRN and CLIC5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		TPRN	CLIC5
Description		taperin	chloride intracellular channel 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microvillus Stereocilium Cell Projection Stereocilium Base	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Stereocilium Monoatomic Ion Channel Complex Chloride Channel Complex Cell Projection Extracellular Exosome
	Molecular Function	Actin Binding Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Phosphatase Binding Protein Phosphatase Binding	Chloride Channel Activity Protein Binding Oxidoreductase Activity
	Biological Process	Sensory Perception Of Sound Auditory Receptor Cell Stereocilium Organization Stereocilium Maintenance	Monoatomic Ion Transport Chloride Transport Female Pregnancy Visual Perception Sensory Perception Of Sound Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Coronary artery disease in type 1 diabetes ( 32077919) Gout (normal type) ( 32238385) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Itch intensity from mosquito bite ( 28199695) LDL cholesterol levels in HIV infection ( 33109212) Mosquito bite size ( 28199695) Periodontal microbiota ( 22699663)
Interacting Genes		9 interacting genes: CLIC1 CLIC2 CLIC4 CLIC5 EPS8 MYO15B PPP1CA PPP1CC WHRN	8 interacting genes: ACTA1 ACTN1 EZR GSN IQGAP1 LAMTOR5 SRPK1 TPRN
Entrez ID		286262	53405
HPRD ID		12977	06292
Ensembl ID		ENSG00000176058	ENSG00000112782
Uniprot IDs		Q4KMQ1	A0A2R8YGW2 Q49AE1 Q53G01 Q9NZA1
PDB IDs		6Y9Q	6Y2H 8Q4I 8Q4J
Enriched GO Terms of Interacting Partners?		Chloride Channel Complex Chloride Channel Activity Chloride Transmembrane Transport Chloride Transport Inorganic Anion Transmembrane Transport Monoatomic Ion Channel Complex Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Stereocilium PTW/PP1 Phosphatase Complex Stereocilium Bundle Stereocilium Tip Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Oxidoreductase Activity Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Brush Border Glycogen Metabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Monoatomic Ion Transport Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Stereocilia Ankle Link USH2 Complex Extracellular Exosome Plasma Membrane Transmembrane Transport Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Termination Of DNA-templated Transcription Dephosphorylation Positive Regulation Of Termination Of RNA Polymerase II Transcription Branching Morphogenesis Of An Epithelial Tube Circadian Rhythm Phosphoprotein Phosphatase Activity Growth Cone Glutamatergic Synapse Dendritic Spine Stereocilia Ankle Link Complex	Actin Filament Actin Filament Organization Actin Cytoskeleton Focal Adhesion Supramolecular Fiber Organization Actin Filament Binding Cortical Actin Cytoskeleton Ruffle Actin Binding Actin Cytoskeleton Organization S100 Protein Binding Establishment Of Epithelial Cell Apical/basal Polarity Actin Filament-based Process Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Polarity Cell-cell Junction Regulation Of Cellular Component Size Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Sarcomere Brush Border Actin Filament Bundle Organization Actin Filament Bundle Assembly Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Microvillus Cytoskeletal Protein Binding Cytosol Cell Development Plasma Membrane Bounded Cell Projection Organization Filopodium Stress Fiber Structural Constituent Of Postsynapse Positive Regulation Of Protein Processing In Phagocytic Vesicle Establishment Of Cell Polarity Terminal Web Assembly Protein Phosphatase Binding Cytoskeleton Organization Muscle Cell Development Cellular Developmental Process Platelet Morphogenesis Cell Projection Organization Protein Localization To Cell Cortex Intestinal D-glucose Absorption Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Stereocilium Maintenance Blood Microparticle
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