TPRN and CLIC2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TPRN	CLIC2
Description		taperin	chloride intracellular channel 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microvillus Stereocilium Cell Projection Stereocilium Base	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Monoatomic Ion Channel Complex Chloride Channel Complex
	Molecular Function	Actin Binding Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Phosphatase Binding Protein Phosphatase Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Chloride Channel Activity Protein Binding Oxidoreductase Activity
	Biological Process	Sensory Perception Of Sound Auditory Receptor Cell Stereocilium Organization Stereocilium Maintenance	Monoatomic Ion Transport Chloride Transport Signal Transduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Monoatomic Ion Transmembrane Transport Cellular Oxidant Detoxification Chloride Transmembrane Transport
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Stimuli-sensing channels Ion homeostasis
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		9 interacting genes: CLIC1 CLIC2 CLIC4 CLIC5 EPS8 MYO15B PPP1CA PPP1CC WHRN	4 interacting genes: NEDD4 NEDD4L TPRN TRAPPC2
Entrez ID		286262	1193
HPRD ID		12977	02139
Ensembl ID		ENSG00000176058	ENSG00000155962
Uniprot IDs		Q4KMQ1	O15247
PDB IDs		6Y9Q	2PER 2R4V 2R5G
Enriched GO Terms of Interacting Partners?		Chloride Channel Complex Chloride Channel Activity Chloride Transmembrane Transport Chloride Transport Inorganic Anion Transmembrane Transport Monoatomic Ion Channel Complex Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Stereocilium PTW/PP1 Phosphatase Complex Stereocilium Bundle Stereocilium Tip Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Oxidoreductase Activity Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Brush Border Glycogen Metabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Monoatomic Ion Transport Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Stereocilia Ankle Link USH2 Complex Extracellular Exosome Plasma Membrane Transmembrane Transport Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Termination Of DNA-templated Transcription Dephosphorylation Positive Regulation Of Termination Of RNA Polymerase II Transcription Branching Morphogenesis Of An Epithelial Tube Circadian Rhythm Phosphoprotein Phosphatase Activity Growth Cone Glutamatergic Synapse Dendritic Spine Stereocilia Ankle Link Complex	Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Transmembrane Transporter Binding Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Transport Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Neuromuscular Junction Development Receptor Metabolic Process Protein Monoubiquitination Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Neuron Projection Development Receptor Internalization Regulation Of Dendrite Morphogenesis Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Cellular Response To UV Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Neuron Projection Development Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Formation Of Structure Involved In A Symbiotic Process Regulation Of Dendrite Development Negative Regulation Of Monoatomic Ion Transport Cellular Response To Light Stimulus Negative Regulation Of Transmembrane Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Regulation Of Cell Projection Organization Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Regulation Of Nucleocytoplasmic Transport Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Channel Inhibitor Activity Nucleoplasm Positive Regulation Of Intracellular Transport N-terminal Peptidyl-lysine Acetylation
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