CLNK and LCP2

Number of citations of the paper that reports this interaction (PubMedID 10562326)
36

Data Source:
HPRD (in vitro)

		CLNK	LCP2
Description		cytokine dependent hematopoietic cell linker	lymphocyte cytosolic protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex Mast Cell Granule	Cytoplasm Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction Mast Cell Degranulation	Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway
Pathways			GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Gout ( 33832965) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 33536424) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)	Acne (severe) ( 24927181) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		29 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		116449	3937
HPRD ID		14720	03362
Ensembl ID		ENSG00000109684	ENSG00000043462
Uniprot IDs		Q7Z7G1	Q13094
PDB IDs			1H3H 1YWO 2EAP 2ROR 6ZCJ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding ErbB-3 Class Receptor Binding Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Tyrosine Kinase Activity ERBB2-EGFR Signaling Pathway Phosphatidylinositol 3-kinase Complex Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Regulation Of Immune System Process Insulin Receptor Substrate Binding Regulation Of Cell Cycle G1/S Phase Transition Insulin-like Growth Factor Receptor Binding ERBB Signaling Pathway Insulin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Ras Protein Signal Transduction Cell-cell Junction Positive Regulation Of Protein Localization To Membrane Schwann Cell Development Kinase Activity Protein Phosphatase Binding Intracellular Signaling Cassette Ruffle Membrane Protein Binding ERBB2 Signaling Pathway Signal Transduction Phosphatidylinositol Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Ephrin Receptor Binding SWI/SNF Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Phosphatidylinositol Metabolic Process Multivesicular Body, Internal Vesicle Lumen Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Intermembrane Phospholipid Transfer Isoprenoid Binding T Cell Activation	Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Intracellular Signal Transduction Leukocyte Activation Signal Transduction Cell Activation Regulation Of MAPK Cascade Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of T Cell Activation Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Activation Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Non-membrane Spanning Protein Tyrosine Kinase Activity Membrane Raft Ephrin Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signal Transduction Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Regulation Of Signaling
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