CLNK and JAKMIP1

		CLNK	JAKMIP1
Description		cytokine dependent hematopoietic cell linker	janus kinase and microtubule interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex Mast Cell Granule	Cytoplasm Cytoskeleton Microtubule Membrane Ribonucleoprotein Complex
	Molecular Function	Protein Binding Protein-containing Complex Binding	RNA Binding Protein Binding Microtubule Binding Kinase Binding GABA Receptor Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction Mast Cell Degranulation	Protein Transport Cognition
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Gout ( 33832965) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 33536424) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)	Coronary artery disease in type 1 diabetes ( 29695241) Response to angiotensin II receptor blocker therapy ( 22566498) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Tau burden ( 33426524)
Interacting Genes		29 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	21 interacting genes: ARK2N BLK CBX8 CHRM3 DDX6 DSCR9 ENKD1 FXR1 GABBR1 IL16 JAK1 MCRS1 MRPL11 PSMB1 SCNM1 TSGA10IP TYK2 USP2 YES1 YWHAG ZNHIT2
Entrez ID		116449	152789
HPRD ID		14720	11292
Ensembl ID		ENSG00000109684	ENSG00000152969
Uniprot IDs		Q7Z7G1	B3KWB6 Q96N16
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding ErbB-3 Class Receptor Binding Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Tyrosine Kinase Activity ERBB2-EGFR Signaling Pathway Phosphatidylinositol 3-kinase Complex Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Regulation Of Immune System Process Insulin Receptor Substrate Binding Regulation Of Cell Cycle G1/S Phase Transition Insulin-like Growth Factor Receptor Binding ERBB Signaling Pathway Insulin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Ras Protein Signal Transduction Cell-cell Junction Positive Regulation Of Protein Localization To Membrane Schwann Cell Development Kinase Activity Protein Phosphatase Binding Intracellular Signaling Cassette Ruffle Membrane Protein Binding ERBB2 Signaling Pathway Signal Transduction Phosphatidylinositol Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Ephrin Receptor Binding SWI/SNF Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Phosphatidylinositol Metabolic Process Multivesicular Body, Internal Vesicle Lumen Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Intermembrane Phospholipid Transfer Isoprenoid Binding T Cell Activation	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT
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