CLNK and NME4

Number of citations: 62 (PubMedID 25814554)
Data Source: BioGRID (two hybrid)

		CLNK	NME4
Name		cytokine dependent hematopoietic cell linker	NME/NM23 nucleoside diphosphate kinase 4
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex Mast Cell Granule	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane
	Molecular Function	Protein Binding Protein-containing Complex Binding	Nucleotide Binding Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding GTPase Binding Phosphatidylglycerol Transfer Activity Mitochondrion-mitochondrion Outer Membrane Tether Activity Cardiolipin Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction Mast Cell Degranulation	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Lipid Transport Nucleoside Metabolic Process Nucleotide Metabolic Process Protein Hexamerization Intermembrane Phospholipid Transfer
Pathways		None	Interconversion of nucleotide di- and triphosphates
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Family history of Alzheimer's disease ( 30617256 ) Gout ( 33832965 ) Resistance to antihypertensive treatment in hypertension ( 28222112 ) Rheumatoid arthritis ( 24390342 30423114 ) Systemic lupus erythematosus ( 28714469 33536424 ) Takayasu arteritis ( 25604533 ) Urate levels ( 31578528 ) Uterine fibroid size (maximum dimension) ( 30196971 ) Vitiligo ( 22561518 )	Body mass index ( 26426971 ) Red blood cell traits ( 23446634 )
Novel Interactors		1 novel interactors: JAKMIP1	None recorded
Interacting Genes		29 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	39 interacting genes: ABI2 AIRIM ARMC7 ATPAF2 C14orf119 CABP2 CABP5 CCDC102B CCDC57 CDKN2D CFAP206 CIB1 CIB3 CIDEB CLNK DTX2 HDAC7 HSF2BP LMO4 LSM8 MKRN3 MLH1 NME1 NME7 NUTF2 NXF1 POLR1C PSMB1 SOCS3 SPG21 SUV39H2 TNS4 TRAPPC2 TRAPPC2B TRIP13 TSSK3 TTC19 UBL5 ZBTB16
Entrez ID		116449	4833
HPRD ID		14720	03489
Ensembl ID		ENSG00000109684	ENSG00000103202
Uniprot IDs		Q7Z7G1	A0A087WVT9 O00746
PDB IDs		Not available	1EHW
GO Terms Enriched among Interactors		Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding ErbB-3 Class Receptor Binding Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Tyrosine Kinase Activity ERBB2-EGFR Signaling Pathway Phosphatidylinositol 3-kinase Complex Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Regulation Of Immune System Process Insulin Receptor Substrate Binding Regulation Of Cell Cycle G1/S Phase Transition Insulin-like Growth Factor Receptor Binding ERBB Signaling Pathway Insulin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Ras Protein Signal Transduction Cell-cell Junction Positive Regulation Of Protein Localization To Membrane Schwann Cell Development Kinase Activity Protein Phosphatase Binding Intracellular Signaling Cassette Ruffle Membrane Protein Binding ERBB2 Signaling Pathway Signal Transduction Phosphatidylinositol Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Ephrin Receptor Binding SWI/SNF Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Phosphatidylinositol Metabolic Process Multivesicular Body, Internal Vesicle Lumen Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Intermembrane Phospholipid Transfer Isoprenoid Binding T Cell Activation	Protein Binding Male Meiotic Nuclear Division Male Germ Cell Nucleus UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process 3'-5'-DNA Exonuclease Activity Female Meiosis I CTP Metabolic Process CTP Biosynthetic Process TRAPPII Protein Complex TRAPPIII Protein Complex Meiosis I Cell Cycle Process Nucleoside Diphosphate Kinase Activity TRAPP Complex Meiotic Nuclear Division Filopodium Tip Female Meiotic Nuclear Division