CLNK and GSTCD

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		CLNK	GSTCD
Description		cytokine dependent hematopoietic cell linker	glutathione S-transferase C-terminal domain containing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex Mast Cell Granule	Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Protein-containing Complex Binding	Molecular_function Protein Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction Mast Cell Degranulation	Biological_process Response To Lipopolysaccharide Respiratory System Development
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Gout ( 33832965) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 33536424) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)	Asthma ( 31959851) Chronic obstructive pulmonary disease ( 28166215) Copper levels ( 26025379) FEV1 ( 30804560) Lung function (FEV1) ( 24023788 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 28166213 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Psoriasis ( 31376382) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Sleep (1/3-day periodicity) ( 33075057)
Interacting Genes		29 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	7 interacting genes: CLNK DAPP1 KDM1A PRMT6 STAT3 SUV39H2 TNS4
Entrez ID		116449	79807
HPRD ID		14720	07823
Ensembl ID		ENSG00000109684	ENSG00000138780
Uniprot IDs		Q7Z7G1	B7Z8J7 Q8NEC7
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding ErbB-3 Class Receptor Binding Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Tyrosine Kinase Activity ERBB2-EGFR Signaling Pathway Phosphatidylinositol 3-kinase Complex Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Regulation Of Immune System Process Insulin Receptor Substrate Binding Regulation Of Cell Cycle G1/S Phase Transition Insulin-like Growth Factor Receptor Binding ERBB Signaling Pathway Insulin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Ras Protein Signal Transduction Cell-cell Junction Positive Regulation Of Protein Localization To Membrane Schwann Cell Development Kinase Activity Protein Phosphatase Binding Intracellular Signaling Cassette Ruffle Membrane Protein Binding ERBB2 Signaling Pathway Signal Transduction Phosphatidylinositol Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Ephrin Receptor Binding SWI/SNF Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Phosphatidylinositol Metabolic Process Multivesicular Body, Internal Vesicle Lumen Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Intermembrane Phospholipid Transfer Isoprenoid Binding T Cell Activation	Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Transcription Regulator Complex Interleukin-10-mediated Signaling Pathway RNA Sequestering Activity Negative Regulation Of Primary MiRNA Processing Cellular Response To Leptin Stimulus Regulation Of Cell Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Postsynapse To Nucleus Signaling Pathway Interleukin-9-mediated Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Interleukin-11-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Protein-containing Complex Retinal Rod Cell Differentiation Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Cellular Response To Interleukin-17 Interleukin-15-mediated Signaling Pathway Negative Regulation Of MiRNA Processing T-helper 17 Type Immune Response Negative Regulation Of Inflammatory Response To Wounding Primary MiRNA Binding DNA-binding Transcription Factor Binding Leptin-mediated Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation CCR5 Chemokine Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3K9 Demethylase Activity Response To Fungicide MRF Binding Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein Demethylase Activity Chromatin Remodeling Telomeric Repeat-containing RNA Binding Regulation Of Signal Transduction By P53 Class Mediator FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Chromatin Organization Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine N-methyltransferase Activity
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