CLNK and P4HA2

Number of citations: 62 (PubMedID 25814554)
Data Source: BioGRID (two hybrid)

		CLNK	P4HA2
Name		cytokine dependent hematopoietic cell linker	prolyl 4-hydroxylase subunit alpha 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex Mast Cell Granule	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol
	Molecular Function	Protein Binding Protein-containing Complex Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction Mast Cell Degranulation	None
Pathways		None	Collagen biosynthesis and modifying enzymes
Drugs		None	Proline
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Family history of Alzheimer's disease ( 30617256 ) Gout ( 33832965 ) Resistance to antihypertensive treatment in hypertension ( 28222112 ) Rheumatoid arthritis ( 24390342 30423114 ) Systemic lupus erythematosus ( 28714469 33536424 ) Takayasu arteritis ( 25604533 ) Urate levels ( 31578528 ) Uterine fibroid size (maximum dimension) ( 30196971 ) Vitiligo ( 22561518 )	Asthma ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 22412388 28067908 ) Giant cell arteritis ( 28041642 ) Height ( 28552196 ) Inflammatory bowel disease ( 28067908 ) Intracranial aneurysm ( 33199917 ) Intraocular pressure ( 29617998 ) Subcortical volume (MOSTest) ( 32665545 ) Sum eosinophil basophil counts ( 27863252 ) Ulcerative colitis ( 28067908 ) Youthful appearance (self-reported) ( 32339537 )
Novel Interactors		1 novel interactors: JAKMIP1	2 novel interactors: CD86 PRKAR2A
Interacting Genes		29 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	7 interacting genes: CLNK CREB3 FHL3 OGT P4HB PRRC2A TNS4
Entrez ID		116449	8974
HPRD ID		14720	11862
Ensembl ID		ENSG00000109684	ENSG00000072682
Uniprot IDs		Q7Z7G1	O15460 Q05DA4
PDB IDs		Not available	6EVL 6EVM 6EVN 6EVO 6EVP 7ZSC
GO Terms Enriched among Interactors		Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding ErbB-3 Class Receptor Binding Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Tyrosine Kinase Activity ERBB2-EGFR Signaling Pathway Phosphatidylinositol 3-kinase Complex Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Regulation Of Immune System Process Insulin Receptor Substrate Binding Regulation Of Cell Cycle G1/S Phase Transition Insulin-like Growth Factor Receptor Binding ERBB Signaling Pathway Insulin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Ras Protein Signal Transduction Cell-cell Junction Positive Regulation Of Protein Localization To Membrane Schwann Cell Development Kinase Activity Protein Phosphatase Binding Intracellular Signaling Cassette Ruffle Membrane Protein Binding ERBB2 Signaling Pathway Signal Transduction Phosphatidylinositol Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Ephrin Receptor Binding SWI/SNF Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Phosphatidylinositol Metabolic Process Multivesicular Body, Internal Vesicle Lumen Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Intermembrane Phospholipid Transfer Isoprenoid Binding T Cell Activation	Focal Adhesion