PLD4

Description		phospholipase D family member 4
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GO Annotations	Cellular Component	Nucleus Lysosome Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endomembrane System Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Phagocytic Vesicle
	Molecular Function	Catalytic Activity Nuclease Activity Exonuclease Activity Phospholipase D Activity Hydrolase Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Immune System Process DNA Metabolic Process Lipid Metabolic Process Phagocytosis Inflammatory Response Innate Immune Response Establishment Of Localization In Cell Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Synthesis of PG Synthesis of IP3 and IP4 in the cytosol Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Rheumatoid arthritis ( 22446963 24390342 30423114 32723749)
Novel Interacting Genes		1 novel interacting genes: TRMT61A
Interacting Genes
Entrez ID		122618
HPRD ID		11230
Ensembl ID		ENSG00000166428
Uniprot IDs		B4DI07 B4DJQ6 F5H2B5 Q96BZ4
PDB IDs		8V08
Enriched GO Terms of Interacting Partners?		MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity TRNA Methylation TRNA Modification RNA Methylation Macromolecule Methylation TRNA Processing RNA Modification TRNA Metabolic Process Methyltransferase Activity Methylation
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