PLD4 and TRMT61A

		PLD4	TRMT61A
Description		phospholipase D family member 4	tRNA methyltransferase 61A
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GO Annotations	Cellular Component	Nucleus Lysosome Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endomembrane System Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Phagocytic Vesicle	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex
	Molecular Function	Catalytic Activity Nuclease Activity Exonuclease Activity Phospholipase D Activity Hydrolase Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Immune System Process DNA Metabolic Process Lipid Metabolic Process Phagocytosis Inflammatory Response Innate Immune Response Establishment Of Localization In Cell Regulation Of Cytokine Production Involved In Inflammatory Response	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation
Pathways		Synthesis of PG Synthesis of IP3 and IP4 in the cytosol Role of phospholipids in phagocytosis	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Rheumatoid arthritis ( 22446963 24390342 30423114 32723749)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Branched-chain amino acid levels (Isoleucine) ( 27898682) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Mean corpuscular volume ( 27863252 32888494) Red blood cell count ( 32888494) Schizophrenia ( 25056061)
Interacting Genes			2 interacting genes: TCL1A TRMT6
Entrez ID		122618	115708
HPRD ID		11230	08810
Ensembl ID		ENSG00000166428	ENSG00000166166
Uniprot IDs		B4DI07 B4DJQ6 F5H2B5 Q96BZ4	Q96FX7
PDB IDs		8V08	5CCB 5CCX 5CD1
Enriched GO Terms of Interacting Partners?		MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity TRNA Methylation TRNA Modification RNA Methylation Macromolecule Methylation TRNA Processing RNA Modification TRNA Metabolic Process Methyltransferase Activity Methylation
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