AHNAK2 and ABLIM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AHNAK2	ABLIM2
Description		AHNAK nucleoprotein 2	actin binding LIM protein family member 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane T-tubule Sarcolemma	Cytoplasm Actin Cytoskeleton
	Molecular Function	Protein Binding	Actin Binding Protein Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Regulation Of RNA Splicing	Cytoskeleton Organization Lamellipodium Assembly
Pathways			DCC mediated attractive signaling
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 26663301 33272962)	Cognitive function ( 28808816) Diffusing capacity of carbon monoxide ( 30694715) Early onset periodontitis x smoking status interaction ( 31537151) Irritable bowel syndrome ( 29626450) Post bronchodilator FEV1 in COPD ( 26634245) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Triacylglyceride levels ( 31551469)
Interacting Genes		16 interacting genes: ABLIM2 ASGR1 C3orf52 CTSA CYB5B CYBC1 FAM3C GABARAPL1 GABARAPL2 IGFBP5 PRAP1 SUMO2 TSPO2 UBIAD1 VAMP3 ZFPL1	6 interacting genes: ABRA AHNAK2 ATP6V0A1 MLIP SREBF2 TTN
Entrez ID		113146	84448
HPRD ID		12261	10623
Ensembl ID		ENSG00000185567	ENSG00000163995
Uniprot IDs		Q8IVF2	A0A140VK02 F5GYR0 Q6H8Q1
PDB IDs		4CN0	1V6G 1WIG 2L3X
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Phosphatidylethanolamine Binding GABA Receptor Binding Negative Regulation Of Skeletal Muscle Hypertrophy Beta-tubulin Binding Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Organelle Membrane Positive Regulation Of Triglyceride Transport 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Autophagosome Maturation Autophagosome Membrane	Endosomal Lumen Acidification Proton-transporting V-type ATPase, V0 Domain Cytoplasm Regulation Of Macroautophagy Regulation Of Metabolic Process Regulation Of Autophagy Synaptic Vesicle Lumen Acidification Proton-transporting V-type ATPase Complex Vacuolar Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Response To Sterol Depletion Regulation Of Amyloid-beta Clearance Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Negative Regulation Of Cholesterol Efflux Regulation Of Gene Expression Positive Regulation Of Lipid Storage Cellular Response To Laminar Fluid Shear Stress Cellular Response To Sterol Depletion SREBP-SCAP-Insig Complex C-8 Sterol Isomerase Activity Negative Regulation Of Cholesterol Transport Positive Regulation Of Macromolecule Biosynthetic Process Response To Laminar Fluid Shear Stress Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Establishment Of Protein Localization Titin-telethonin Complex Protein Kinase A Signaling Muscle Alpha-actinin Binding Mitotic Chromosome Condensation Detection Of Muscle Stretch Protein Kinase Regulator Activity Structural Molecule Activity Conferring Elasticity Actin-myosin Filament Sliding Striated Muscle Thin Filament Myosin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Actin Cytoskeleton Organization Actin Cytoskeleton Cardiac Myofibril Assembly Sarcomerogenesis Muscle Filament Sliding Actinin Binding Telethonin Binding Skeletal Muscle Thin Filament Assembly Sarcolemma Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
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