POLR3C and VAX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLR3C	VAX1
Description		RNA polymerase III subunit C	ventral anterior homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytosol	Chromatin Nucleus
	Molecular Function	DNA Binding Single-stranded DNA Binding DNA-directed RNA Polymerase Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Immune System Process DNA-templated Transcription Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Axon Guidance Central Nervous System Development Brain Development Glial Cell Differentiation Neuron Differentiation Skeletal Muscle Cell Differentiation Camera-type Eye Development Astrocyte Differentiation Roof Of Mouth Development Neuroepithelial Cell Differentiation
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS			Age at first birth ( 34211149) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 20023658)
Interacting Genes		38 interacting genes: ANKRD23 APP CAMK2B CEP44 CEP63 COIL DISC1 ENKD1 GOLGA2 GTF3C4 HAUS1 INCA1 KATNBL1 KIAA0408 KLHL2 KPNA1 KPNA3 KPNA5 KPNA6 KRT75 LZTS1 NCKIPSD OGT PAX6 PICK1 PNMA5 POU6F2 PRDM16 RBBP8NL ROCK1 ROPN1 SP100 TNR TRAF2 TRIM27 UBXN1 VAX1 VRTN	14 interacting genes: DVL3 EAF1 ESRRG HECW1 HMBOX1 MLLT3 PICK1 POLR3C PSMB1 RCOR3 RPRD1B SDCBP2 SPANXN2 USP20
Entrez ID		10623	11023
HPRD ID		17880	16052
Ensembl ID		ENSG00000186141	ENSG00000148704
Uniprot IDs		Q9BUI4	Q5SQQ9
PDB IDs		2XUB 2XV4 5AFQ 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Spindle Pole Regulation Of Synapse Organization Microtubule-based Process Regulation Of Postsynapse Organization Negative Regulation Of Catabolic Process Regulation Of Synapse Maturation Viral Penetration Into Host Nucleus Microtubule Organizing Center Organization Cytoskeleton Organization Microtubule Cytoskeleton Organization Identical Protein Binding Protein Localization To Organelle Regulation Of Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Intracellular Transport Of Virus Regulation Of Neuroblast Proliferation Protein Import Into Nucleus Cytoplasm Centrosome Cycle Import Into Nucleus Host Cell Regulation Of Supramolecular Fiber Organization Cytoskeleton Postsynaptic Density Nucleoplasm Regulation Of Cell Junction Assembly Central Nervous System Development Membraneless Organelle Assembly Negative Regulation Of Neuroblast Proliferation Arp2/3 Complex Binding Regulation Of Synapse Assembly Centriole Cell Projection Organization Regulation Of Cellular Component Organization Negative Regulation Of Viral Transcription Negative Regulation Of Protein Ubiquitination Cytosol Organelle Organization Protein Localization To Nucleus Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organismal Process Regulation Of Amyloid-beta Clearance Organelle Assembly Regulation Of Viral Transcription TOR Signaling Chromatin DNA Binding
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