POLR3C and GTF3C4

Number of citations of the paper that reports this interaction (PMID 10523658)
26

Data Source:
HPRD (in vivo, in vitro)

		POLR3C	GTF3C4
Gene Name		polymerase (RNA) III (DNA directed) polypeptide C (62kD)	general transcription factor IIIC, polypeptide 4, 90kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase III Complex Cytosol	Transcription Factor TFIIIC Complex Nucleoplasm
	Molecular Function	RNA Polymerase III Activity DNA Binding DNA-directed RNA Polymerase Activity	DNA Binding Histone Acetyltransferase Activity Protein Binding Enzyme Activator Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase III Promoter Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter Transcription Initiation From RNA Polymerase III Promoter Gene Expression Histone Acetylation 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Positive Regulation Of Catalytic Activity
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Initiation From Type 2 Promoter Innate Immune System	RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: APP CEP63 GTF3C4 PNMA5 ROCK1 ROPN1 TNR TRIM27	11 interactors: BRCA1 BRF1 GTF3C1 GTF3C2 GTF3C5 GTF3C6 HIST2H3A HIST3H3 POLR3C POLR3F TBP
Entrez ID		10623	9329
HPRD ID		17880	11998
Ensembl ID		ENSG00000186141
Uniprot IDs		Q9BUI4	B3KNH2 Q9UKN8
PDB IDs		2XUB 2XV4
Enriched GO Terms of Interacting Partners?		Axon Guidance Neuromuscular Process Controlling Balance Associative Learning Negative Regulation Of Axon Extension Involved In Regeneration Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Neuromuscular Process Neuron Projection Morphogenesis Learning Collateral Sprouting In Absence Of Injury Cell Morphogenesis Involved In Differentiation Synapse Organization Cellular Component Assembly Neuron Projection Development Negative Regulation Of Neuron Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Membrane To Membrane Docking Cell Projection Morphogenesis Cell Part Morphogenesis 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Import Apical Constriction Axon Choice Point Recognition TRNA Transcription Locomotory Behavior Neuron Development Negative Regulation Of Axon Regeneration Positive Regulation Of Transmission Of Nerve Impulse Interferon-gamma Secretion Learning Or Memory Neuron Remodeling Cell Morphogenesis Bleb Assembly Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Cognition Cytoskeleton Organization Neuron Differentiation Cell Projection Organization Regulation Of Transmission Of Nerve Impulse Centriole Replication Locomotory Exploration Behavior Positive Regulation Of Cellular Component Biogenesis	Transcription From RNA Polymerase III Promoter TRNA Transcription 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter RRNA Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase III Promoter Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Termination DNA-templated Transcription, Elongation RNA Metabolic Process Biosynthetic Process Chromatin Silencing At RDNA Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Interferon-beta Production Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Chromatin Silencing Regulation Of Interferon-beta Production Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Cytokine Production Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production Positive Regulation Of Histone H3-K9 Acetylation Gene Silencing Regulation Of Type I Interferon Production Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Proepicardium Development Regulation Of Cytokine Production Cellular Response To Indole-3-methanol Defense Response To Virus Metabolic Process Negative Regulation Of Centriole Replication Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Innate Immune Response Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation
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