POLR3C and ANKRD23

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLR3C	ANKRD23
Description		RNA polymerase III subunit C	ankyrin repeat domain 23
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Intercalated Disc Actin Cytoskeleton Myofibril I Band
	Molecular Function	DNA Binding Single-stranded DNA Binding DNA-directed RNA Polymerase Activity Protein Binding	Transcription Cis-regulatory Region Binding Protein Binding Titin Binding
	Biological Process	Immune System Process DNA-templated Transcription Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus	Fatty Acid Metabolic Process Response To Mechanical Stimulus Response To Muscle Stretch Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Sarcomere Organization
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756)
Interacting Genes		38 interacting genes: ANKRD23 APP CAMK2B CEP44 CEP63 COIL DISC1 ENKD1 GOLGA2 GTF3C4 HAUS1 INCA1 KATNBL1 KIAA0408 KLHL2 KPNA1 KPNA3 KPNA5 KPNA6 KRT75 LZTS1 NCKIPSD OGT PAX6 PICK1 PNMA5 POU6F2 PRDM16 RBBP8NL ROCK1 ROPN1 SP100 TNR TRAF2 TRIM27 UBXN1 VAX1 VRTN	20 interacting genes: CCDC102B CCDC57 CDCA7L CLIC3 ENKD1 FAM90A1 GRB2 HOOK1 HRAS IQUB KDM1A KIFC3 MIPOL1 MYPN NAP1L1 PIBF1 POLR3C SMARCD1 TRIM41 TTN
Entrez ID		10623	200539
HPRD ID		17880	12462
Ensembl ID		ENSG00000186141	ENSG00000163126
Uniprot IDs		Q9BUI4	Q86SG2
PDB IDs		2XUB 2XV4 5AFQ 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Spindle Pole Regulation Of Synapse Organization Microtubule-based Process Regulation Of Postsynapse Organization Negative Regulation Of Catabolic Process Regulation Of Synapse Maturation Viral Penetration Into Host Nucleus Microtubule Organizing Center Organization Cytoskeleton Organization Microtubule Cytoskeleton Organization Identical Protein Binding Protein Localization To Organelle Regulation Of Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Intracellular Transport Of Virus Regulation Of Neuroblast Proliferation Protein Import Into Nucleus Cytoplasm Centrosome Cycle Import Into Nucleus Host Cell Regulation Of Supramolecular Fiber Organization Cytoskeleton Postsynaptic Density Nucleoplasm Regulation Of Cell Junction Assembly Central Nervous System Development Membraneless Organelle Assembly Negative Regulation Of Neuroblast Proliferation Arp2/3 Complex Binding Regulation Of Synapse Assembly Centriole Cell Projection Organization Regulation Of Cellular Component Organization Negative Regulation Of Viral Transcription Negative Regulation Of Protein Ubiquitination Cytosol Organelle Organization Protein Localization To Nucleus Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organismal Process Regulation Of Amyloid-beta Clearance Organelle Assembly Regulation Of Viral Transcription TOR Signaling Chromatin DNA Binding	Cytoskeleton Organization Centrosome Cellular Response To Ionizing Radiation Schwann Cell Development Microtubule-based Process Muscle Alpha-actinin Binding Cilium Assembly Positive Regulation Of Multicellular Organismal Process Cilium Organization I Band Cellular Response To Gamma Radiation Response To Ionizing Radiation Plasma Membrane Bounded Cell Projection Assembly
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