C1QTNF1 and TGM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C1QTNF1	TGM1
Description		C1q and TNF related 1	transglutaminase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Plasma Membrane	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Collagen Binding Identical Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Platelet Aggregation Positive Regulation Of Aldosterone Secretion	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development
Pathways			Formation of the cornified envelope
Drugs
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS
Interacting Genes		11 interacting genes: AVPR2 C14orf119 C1QTNF6 CACNA1A LMNA LNX1 PRPF31 SGTA TGM1 UBL5 UBQLN4	34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4
Entrez ID		114897	7051
HPRD ID		12714	01824
Ensembl ID		ENSG00000173918	ENSG00000092295
Uniprot IDs		A0A0C4DFP7 A0A3B0J271 Q9BXJ1	P22735
PDB IDs			2XZZ
Enriched GO Terms of Interacting Partners?		Identical Protein Binding	Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity
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