C1QTNF1 and AVPR2

Number of citations of the paper that reports this interaction (PubMedID 12409230)
0

Data Source:
HPRD (two hybrid, in vitro)

		C1QTNF1	AVPR2
Description		C1q and TNF related 1	arginine vasopressin receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Plasma Membrane	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Collagen Binding Identical Protein Binding	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Platelet Aggregation Positive Regulation Of Aldosterone Secretion	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Retention Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Hemostasis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Telencephalon Development Cellular Response To Hormone Stimulus Response To Cytokine Negative Regulation Of Urine Volume Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Renal Water Absorption Positive Regulation Of Intracellular Signal Transduction
Pathways			Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
Drugs			Desmopressin Vasopressin Demeclocycline Conivaptan Terlipressin M0002 OPC-51803 Tolvaptan Atosiban Lypressin Pecavaptan
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS
Interacting Genes		11 interacting genes: AVPR2 C14orf119 C1QTNF6 CACNA1A LMNA LNX1 PRPF31 SGTA TGM1 UBL5 UBQLN4	10 interacting genes: ARRB2 AVP C1QTNF1 COMT FXYD6-FXYD2 GNAS GNB1 GNG2 GRK5 SLC41A1
Entrez ID		114897	554
HPRD ID		12714	02368
Ensembl ID		ENSG00000173918	ENSG00000126895
Uniprot IDs		A0A0C4DFP7 A0A3B0J271 Q9BXJ1	P30518
PDB IDs			4JQI 6NI2 6U1N 7BB6 7BB7 7DF9 7DFA 7DFB 7DFC 7DW9 7KH0 7R0C 7R0J 8GOC 8I10 8JRU 8JRV 8WRZ 8WU1 9BT8 9CX3 9CX9
Enriched GO Terms of Interacting Partners?		Identical Protein Binding	Response To Catecholamine Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Cellular Response To Prostaglandin E Stimulus Response To Alcohol G Protein-coupled Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Heterotrimeric G-protein Complex Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway D1 Dopamine Receptor Binding Renal System Process G Protein-coupled Receptor Signaling Pathway Response To Lipid Multicellular Organismal-level Water Homeostasis Regulation Of System Process Renal Absorption Response To Hormone Postsynaptic Signal Transduction Regulation Of Body Fluid Levels V1B Vasopressin Receptor Binding Norepinephrine Secretion Catechol O-methyltransferase Activity Plasma Membrane Multicellular Organismal Response To Stress Multicellular Organismal-level Chemical Homeostasis System Process Cellular Response To Hormone Stimulus Positive Regulation Of Transport Angiotensin Receptor Binding Nervous System Process V1A Vasopressin Receptor Binding Neurohypophyseal Hormone Activity Cellular Response To Phosphate Starvation Cellular Response To Oxygen-containing Compound Mu-type Opioid Receptor Binding Magnesium:sodium Antiporter Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Sensory Perception Of Chemical Stimulus Positive Regulation Of Aldosterone Secretion Sensory Perception Negative Regulation Of Female Receptivity Maternal Aggressive Behavior Protein Localization To Extracellular Region Habituation Mastication Establishment Of Protein Localization To Extracellular Region Renal Sodium Excretion
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