C1QTNF1 and AVPR2

Number of citations of the paper that reports this interaction (PMID 12409230)
1

Data Source:
HPRD (in vitro, two hybrid)

		C1QTNF1	AVPR2
Gene Name		C1q and tumor necrosis factor related protein 1	arginine vasopressin receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Collagen Trimer Extracellular Space Integral Component Of Plasma Membrane	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Collagen Binding	Vasopressin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Protein Homooligomerization Positive Regulation Of Protein Kinase B Signaling Protein Heterotrimerization Negative Regulation Of Platelet Aggregation Positive Regulation Of Aldosterone Secretion	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Water Transport Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity I-kappaB Kinase/NF-kappaB Signaling Excretion Hemostasis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Telencephalon Development Positive Regulation Of Protein Ubiquitination Interferon-gamma Production Cellular Response To Hormone Stimulus Response To Cytokine Negative Regulation Of Urine Volume Negative Regulation Of Renal Sodium Excretion Positive Regulation Of Vasoconstriction Transmembrane Transport Response To Peptide
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Aquaporin-mediated transport GPCR ligand binding GPCR downstream signaling Peptide ligand-binding receptors
Drugs			Desmopressin Vasopressin Conivaptan Terlipressin Tolvaptan
Diseases
GWAS
Protein-Protein Interactions		6 interactors: AVPR2 CACNA1A LNX1 PRPF31 SGTA UBQLN4	7 interactors: ARRB2 AVP C1QTNF1 GNAS GNB1 GNG2 GRK5
Entrez ID		114897	554
HPRD ID		12714	02368
Ensembl ID		ENSG00000173918	ENSG00000126895
Uniprot IDs		Q9BXJ1	P30518
PDB IDs			4JQI
Enriched GO Terms of Interacting Partners?		Cerebellar Molecular Layer Development Vestibular Nucleus Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Negative Regulation Of Urine Volume Regulation Of Systemic Arterial Blood Pressure By Vasopressin Rhythmic Synaptic Transmission Negative Regulation Of Renal Sodium Excretion Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Spliceosomal Tri-snRNP Complex Assembly Negative Regulation Of Hormone Biosynthetic Process Pons Development Positive Regulation Of Systemic Arterial Blood Pressure Cerebellar Purkinje Cell Differentiation	Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dopamine Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Platelet Activation Regulation Of Body Fluid Levels Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Glucagon Response To Fatty Acid Generation Of Precursor Metabolites And Energy Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Acid Chemical Wound Healing Cytosolic Calcium Ion Homeostasis Regulation Of Signal Transduction Cell Activation Response To Wounding Renal Water Homeostasis Regulation Of Signaling Negative Regulation Of Mitochondrion Organization Response To Organonitrogen Compound Response To Lipid Chemical Homeostasis Response To Organic Cyclic Compound Cellular Calcium Ion Homeostasis Water Transport Energy Derivation By Oxidation Of Organic Compounds Calcium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus Response To Hormone Fluid Transport Cellular Response To Peptide Apoptotic Process Multicellular Organismal Water Homeostasis Programmed Cell Death Cell Death Death Water Homeostasis
Tagcloud ?			aqp2 aquaporin asked congenital d85n ddavp desmopressin details diuretics endocrinology insipidus japan japanese ndi nephrogenic nephrology neurology polyuria prognoses retardation revealing siblings society thiazide uncertainty urologic urological urology vasopressin
Tagcloud (Difference) ?			aqp2 aquaporin asked congenital d85n ddavp desmopressin details diuretics endocrinology insipidus japan japanese ndi nephrogenic nephrology neurology polyuria prognoses retardation revealing siblings society thiazide uncertainty urologic urological urology vasopressin
Tagcloud (Intersection) ?