RETREG1 and MORC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RETREG1	MORC3
Description		reticulophagy regulator 1	MORC family CW-type zinc finger 3
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GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Nuclear Body	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Matrix PML Body
	Molecular Function	Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity	DNA Binding RNA Binding Protein Binding Zinc Ion Binding ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	Mitophagy Autophagy Endoplasmic Reticulum Organization Sensory Perception Of Pain Collagen Catabolic Process Negative Regulation Of Neuron Apoptotic Process White Fat Cell Differentiation Reticulophagy Substrate Localization To Autophagosome	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Chromatin Organization Protein Phosphorylation Post-embryonic Development Peptidyl-serine Phosphorylation Negative Regulation Of Interferon-beta Production Innate Immune Response Negative Regulation Of Fibroblast Proliferation Protein Stabilization Maintenance Of Protein Location In Nucleus Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Cellular Senescence
Pathways
Drugs
Diseases
GWAS		Diffusing capacity of carbon monoxide ( 30694715) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227)	Diastolic blood pressure ( 30224653) Height ( 31562340)
Interacting Genes		7 interacting genes: AMFR APP BDKRB1 GABARAPL2 MAP1LC3B MORC3 SNAPIN	25 interacting genes: ARK2N COPS5 DST DYNLL1 ERCC6 KALRN KIF3A KPNA2 KPNA4 MKLN1 PIAS1 PIAS3 PTK2 RANBP9 RETREG1 RNF123 RNF216 SNAPIN SPTBN4 SRI SUMO2 SUMO3 UBC UBE2I ZMYM5
Entrez ID		54463	23515
HPRD ID		07879	10316
Ensembl ID		ENSG00000154153	ENSG00000159256
Uniprot IDs		A0A804HHX5 Q9H6L5	B4DHJ4 Q14149 Q4VBZ9
PDB IDs		7BRQ 7FB5	4QQ4 5SVI 5SVX 5SVY 6O1E 6O5W
Enriched GO Terms of Interacting Partners?		Autophagosome Maturation Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein-containing Complex Disassembly Vacuole Organization Response To Stress Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytoplasmic Vesicle Mitophagy Autophagosome Membrane Autophagy Of Mitochondrion SNARE Binding Positive Regulation Of Late Endosome To Lysosome Transport Axo-dendritic Transport Autophagosome Protein-folding Chaperone Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Bradykinin Receptor Activity Autophagosome Organization Autophagosome Assembly Golgi Apparatus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Phospholipid Binding Negative Regulation Of Canonical Wnt Signaling Pathway Protein-containing Complex Organization Growth Cone BAT3 Complex Binding Regulation Of Calcium Ion Transmembrane Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Positive Regulation Of Leukocyte Migration Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Endoplasmic Reticulum Negative Regulation Of Wnt Signaling Pathway	Protein Sumoylation SUMO Transferase Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Post-translational Protein Modification PML Body Protein Modification Process Protein Tag Activity Axon Cytoplasm Protein Metabolic Process Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Nucleoplasm Macromolecule Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Transport Microtubule Anchoring At Centrosome Cellular Localization Axonal Transport Negative Regulation Of Heart Rate SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Microtubule Anchoring At Microtubule Organizing Center Transport Along Microtubule Cell Cortex Axo-dendritic Transport Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Cytosol Microtubule-based Transport Nuclear Import Signal Receptor Activity Retrograde Axonal Transport Negative Regulation Of Heart Contraction Cytoplasm Enzyme Binding Nuclear Localization Sequence Binding Negative Regulation Of Blood Circulation Regulation Of Protein Sumoylation NLS-bearing Protein Import Into Nucleus Microtubule Anchoring Regulation Of Protein Modification Process Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Spectrin Binding Proteolysis Involved In Protein Catabolic Process Establishment Of Organelle Localization Vesicle Localization
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