TMC6 and CCR9

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TMC6	CCR9
Description		transmembrane channel like 6	C-C motif chemokine receptor 9
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Nuclear Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Mechanosensitive Monoatomic Ion Channel Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Intracellular Zinc Ion Homeostasis Monoatomic Ion Transmembrane Transport Protein Stabilization	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Vercirnon
Diseases		Epidermodysplasia verruciformis
GWAS		Glycated hemoglobin levels ( 31213470 34059833 29170429 28887542) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 32327693) hemolysis of donated blood (cold-storage) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 27863252 29403010 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum uric acid levels ( 29559957)	Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		3 interacting genes: CCR9 ZBTB2 ZDHHC17	19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE
Entrez ID		11322	10803
HPRD ID		08386	09200
Ensembl ID		ENSG00000141524	ENSG00000173585
Uniprot IDs		A0A8V8TLY1 Q7Z403	B2R734 P51686
PDB IDs			5LWE
Enriched GO Terms of Interacting Partners?		CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Gamma-delta T Cell Differentiation Gamma-delta T Cell Activation Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Protein Lipidation	Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity
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