GPR45 and OTX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR45	OTX2
Description		G protein-coupled receptor 45	orthodenticle homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Chromatin Nucleus Growth Cone Protein-containing Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation
Pathways		G alpha (s) signalling events	Formation of the anterior neural plate Formation of the posterior neural plate
Drugs
Diseases			Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Body mass index ( 26426971) Menarche (age at onset) ( 25231870 27182965)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Lung cancer ( 31577861) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: OTX2	44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1
Entrez ID		11250	5015
HPRD ID		05325	07190
Ensembl ID		ENSG00000135973	ENSG00000165588
Uniprot IDs		B5B0C1 Q9Y5Y3	F1T0C9 F1T0D0 F1T0D1 P32243
PDB IDs
Enriched GO Terms of Interacting Partners?		Primitive Streak Formation Positive Regulation Of Embryonic Development Eukaryotic Initiation Factor 4E Binding Positive Regulation Of Gastrulation Regulation Of Gastrulation Doxorubicin Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Ethanol Metabolic Process Flavonoid Metabolic Process Sulfation Aryl Sulfotransferase Activity Ethanol Catabolic Process Error-free Translesion Synthesis Deoxycytidyl Transferase Activity Error-prone Translesion Synthesis DNA-directed DNA Polymerase Activity Translesion Synthesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Midbrain Development Dopaminergic Neuron Differentiation Alcohol Catabolic Process Postreplication Repair Sulfotransferase Activity Phosphatidylinositol-3,4,5-trisphosphate Binding DNA Synthesis Involved In DNA Repair Secondary Metabolic Process	Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II
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