NSA2 and IRAK3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NSA2	IRAK3
Gene Name		NSA2 ribosome biogenesis homolog (S. cerevisiae)	interleukin-1 receptor-associated kinase 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Ribonucleoprotein Complex	Nucleus Cytoplasm Interleukin-1 Receptor Complex
	Molecular Function	Poly(A) RNA Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	RRNA Processing	Negative Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways			Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Cytokine Signaling in Immune system Interleukin-1 signaling Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: IRAK3	17 interactors: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		10412	11213
HPRD ID		18191	05123
Ensembl ID		ENSG00000164346	ENSG00000090376
Uniprot IDs		O95478 Q5J7U2	Q9Y616
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Response To Peptidoglycan Interleukin-1-mediated Signaling Pathway Negative Regulation Of Interleukin-12 Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Innate Immune Response Negative Regulation Of Interleukin-6 Production Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Exogenous DsRNA Cellular Response To Interleukin-1 Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interleukin-12 Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Response To DsRNA Negative Regulation Of MAP Kinase Activity Response To Interleukin-1 Negative Regulation Of Protein Complex Disassembly Regulation Of Tumor Necrosis Factor Production Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Regulation Of Protein Complex Disassembly Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity Activation Of Innate Immune Response Negative Regulation Of MAPK Cascade Positive Regulation Of Innate Immune Response Negative Regulation Of Cytokine Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autophosphorylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Innate Immune Response Response To Virus Regulation Of MAP Kinase Activity Negative Regulation Of Transferase Activity Response To Lipopolysaccharide Negative Regulation Of Protein Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Lipid Regulation Of Innate Immune Response Response To Lipopolysaccharide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Molecule Of Bacterial Origin Toll-like Receptor 9 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 JNK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Lipid Regulation Of Immune Response Regulation Of Immune System Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of MAPK Activity Lipopolysaccharide-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Immune Response Response To Cytokine Response To Other Organism Response To Biotic Stimulus Cellular Response To Interleukin-1 Inflammatory Response Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction
Tagcloud ?			a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Difference) ?			a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Intersection) ?