KLK8 and KRTAP5-9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLK8	KRTAP5-9
Description		kallikrein related peptidase 8	keratin associated protein 5-9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Serine Protease Inhibitor Complex	Cytosol Intermediate Filament
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Memory Response To Wounding Keratinocyte Proliferation Neuron Projection Morphogenesis Regulation Of Synapse Organization Synapse Organization Protein Maturation	Epidermis Development
Pathways		Formation of the cornified envelope	Keratinization
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		12 interacting genes: CYSRT1 KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP5-9 KRTAP9-3 NBPF19 NOTCH2NLA RGS2	201 interacting genes: ABHD17A ADAM12 ADAMTSL4 ADAMTSL5 ALDH3B1 ALPP ATG9A BEX2 BMP7 BRME1 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CHRNG CKS1B CNNM3 COL8A1 COMT CRCT1 CREB5 CRH CRY2 CTNNBIP1 CTSZ CXCL16 CYSRT1 DCDC2 DHRS1 DMRT3 DNASE1L3 DOCK2 EMC7 ENKD1 ENPP7 FAH FAM124B FAM161A FAM74A4 FAM76B FLT3LG GGN GLP1R GLRX3 GNE GRN GSC2 HEY2 HHEX HLCS HOXA1 HOXB9 HPCAL1 HSD3B7 HSPD1 ICAM4 IGFBP6 JOSD1 KLHL38 KLK8 KPRP KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 LY6H MAPKBP1 MEOX2 MOBP MT1M NAXD NBPF19 NCLN NECTIN2 NECTIN3 NKD1 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NR4A3 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 P2RY6 P4HB PCSK5 PDE9A PFKL PGAP6 PGLS PHLDA1 PIN1 POM121L8P POTEB3 POU4F2 PRKAB2 PSMA1 PTK7 PTPMT1 RAMP3 RASD1 RGS20 RNF111 SCARB1 SCNM1 SDC3 SDCBP SEMA3B SHFL SLC13A5 SLC15A3 SLC22A23 SLC25A10 SLC6A20 SMCP SPATA3 SPATC1L SPG7 SPINK2 SPRY1 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TGM1 TOMM22 TRARG1 TYRO3 UBE2I UXT VWC2 WNT11 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF581 ZNF587 ZNF655 ZNF696 ZNF837
Entrez ID		11202	3846
HPRD ID		05733	01008
Ensembl ID		ENSG00000129455	ENSG00000254997
Uniprot IDs		A0A0A0MQY9 O60259	P26371
PDB IDs		5MS3 5MS4
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Epidermis Development Structural Constituent Of Skin Epidermis Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Tissue Development Intermediate Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytosol Adenylate Cyclase Inhibitor Activity	Intermediate Filament Keratin Filament Keratinization Epidermis Development Protein Binding Tissue Development Hair Cycle Axis Elongation
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