KLK8 and RGS2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		KLK8	RGS2
Gene Name		kallikrein-related peptidase 8	regulator of G-protein signaling 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Proteolysis Memory Cell Death Response To Wounding Negative Regulation Of Myelination Keratinocyte Proliferation Negative Regulation Of Axon Regeneration Neuron Projection Morphogenesis Regulation Of Synapse Organization Synapse Organization	Regulation Of Translation Cell Cycle Spermatogenesis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Microtubule Polymerization Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Smooth Muscle Positive Regulation Of Cardiac Muscle Contraction Regulation Of Adrenergic Receptor Signaling Pathway
Pathways			G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: KRTAP10-3 NOTCH2NL RGS2	58 interactors: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CHD3 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KIAA1377 KLK8 LIG1 LRFN1 METTL18 MON1A MTUS2 NINL NIPSNAP1 PARK2 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		11202	5997
HPRD ID		05733	02917
Ensembl ID		ENSG00000129455	ENSG00000116741
Uniprot IDs		O60259	P41220
PDB IDs			2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?		Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Relaxation Of Smooth Muscle Negative Regulation Of Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Positive Regulation Of Microtubule Polymerization Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Cardiac Muscle Hypertrophy Vasodilation Brown Fat Cell Differentiation Regulation Of Smooth Muscle Contraction Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Cardiac Muscle Contraction Negative Regulation Of MAP Kinase Activity Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Polymerization Fat Cell Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Notch Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Muscle Contraction Negative Regulation Of MAPK Cascade Regulation Of Heart Contraction Regulation Of Microtubule-based Process Positive Regulation Of Protein Complex Assembly Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity	Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Platelet Activation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Wounding Blood Coagulation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Hemostasis Wound Healing Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Nervous System Development Regulation Of Cyclase Activity Activation Of Adenylate Cyclase Activity Signaling Response To Stress Neurotrophin Signaling Pathway Cell Communication Regulation Of Phosphorylation Dopamine Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Developmental Process Positive Regulation Of Adenylate Cyclase Activity Regulation Of Kinase Activity Response To Organic Substance Cellular Response To Stimulus Regulation Of Muscle Contraction Anatomical Structure Development Regulation Of CAMP Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Hydrolase Activity Cell Activation Membrane Organization Regulation Of CAMP Metabolic Process Regulation Of Protein Phosphorylation System Development Positive Regulation Of Lyase Activity Enzyme Linked Receptor Protein Signaling Pathway Golgi Vesicle Budding Adrenergic Receptor Signaling Pathway
Tagcloud ?		adamts adamts5deltacat aggrecan capn2 cartilage col10a1 crlf1 degradome destabilization destabilized dmm dysregulated erosion foxo4 hybridized il11 inhba joints meniscus microdissection mmp3 oa phdla2 postsurgery priorities prss46 ptgs2 sentinel xbp1	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Difference) ?		adamts adamts5deltacat aggrecan capn2 cartilage col10a1 crlf1 degradome destabilization destabilized dmm dysregulated erosion foxo4 hybridized il11 inhba joints meniscus microdissection mmp3 oa phdla2 postsurgery priorities prss46 ptgs2 sentinel xbp1	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Intersection) ?