KLK8 and NOTCH2NL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KLK8	NOTCH2NL
Gene Name		kallikrein-related peptidase 8	notch 2 N-terminal like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Extracellular Region Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Calcium Ion Binding
	Biological Process	Proteolysis Memory Cell Death Response To Wounding Negative Regulation Of Myelination Keratinocyte Proliferation Negative Regulation Of Axon Regeneration Neuron Projection Morphogenesis Regulation Of Synapse Organization Synapse Organization	Notch Signaling Pathway Multicellular Organismal Development Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: KRTAP10-3 NOTCH2NL RGS2	241 interactors: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 AES ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C16orf59 C19orf66 C5orf60 CA6 CARHSP1 CARKD CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 HBZ HCK HIST1H2AK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MFI2 MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLSCR4 POLR2G POM121L8P POMGNT2 PPAP2C PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR PVRL2 PVRL3 QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELM SEMA4C SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 THAP7 THEMIS2 TINAGL1 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587
Entrez ID		11202	388677
HPRD ID		05733	14833
Ensembl ID		ENSG00000129455	ENSG00000213240
Uniprot IDs		O60259	Q7Z3S9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Relaxation Of Smooth Muscle Negative Regulation Of Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Positive Regulation Of Microtubule Polymerization Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Cardiac Muscle Hypertrophy Vasodilation Brown Fat Cell Differentiation Regulation Of Smooth Muscle Contraction Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Cardiac Muscle Contraction Negative Regulation Of MAP Kinase Activity Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Polymerization Fat Cell Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Notch Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Muscle Contraction Negative Regulation Of MAPK Cascade Regulation Of Heart Contraction Regulation Of Microtubule-based Process Positive Regulation Of Protein Complex Assembly Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity	Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Locomotion Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Response To Lipid Cell Motility Cellular Response To Lipid Movement Of Cell Or Subcellular Component Response To Lipopolysaccharide Positive Regulation Of Immune Response To Tumor Cell RNA Biosynthetic Process Transcription, DNA-templated System Development Response To Molecule Of Bacterial Origin Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To External Stimulus Susceptibility To T Cell Mediated Cytotoxicity Formation Of Primary Germ Layer Cellular Response To Stimulus Cellular Process Negative Regulation Of Transcription, DNA-templated Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Protein Metabolic Process Biosynthetic Process Endodermal Cell Differentiation Cell Migration Regulation Of Metabolic Process Regulation Of Cellular Process Response To Stimulus Gene Expression Nitrogen Compound Metabolic Process Organ Development Keratinization Anatomical Structure Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Neutrophil Mediated Immunity Extracellular Matrix Organization Extracellular Structure Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Carbon Dioxide Transport Gastrulation Cellular Macromolecule Biosynthetic Process Tissue Development Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Tagcloud ?		adamts adamts5deltacat aggrecan capn2 cartilage col10a1 crlf1 degradome destabilization destabilized dmm dysregulated erosion foxo4 hybridized il11 inhba joints meniscus microdissection mmp3 oa phdla2 postsurgery priorities prss46 ptgs2 sentinel xbp1	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Difference) ?		adamts adamts5deltacat aggrecan capn2 cartilage col10a1 crlf1 degradome destabilization destabilized dmm dysregulated erosion foxo4 hybridized il11 inhba joints meniscus microdissection mmp3 oa phdla2 postsurgery priorities prss46 ptgs2 sentinel xbp1	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Intersection) ?