PKP3 and JUP

Number of citations of the paper that reports this interaction (PubMedID 12707304)
49

Data Source:
BioGRID (two hybrid)

		PKP3	JUP
Description		plakophilin 3	junction plakoglobin
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Membrane Cell Junction Desmosome Anchoring Junction	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Anchoring Junction Catenin-TCF7L2 Complex Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Protein Binding Enzyme Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cadherin Binding Involved In Cell-cell Adhesion	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Nuclear Receptor Binding Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Desmosome Assembly Regulation Of Cytokine Production Involved In Immune Response Desmosome Organization Regulation Of Translation Cell Adhesion Regulation Of Gene Expression Epithelial Structure Maintenance Positive Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Regulation Of Hair Follicle Development Protein Localization To Plasma Membrane Epithelial Cell-cell Adhesion Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Adhesion Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Canonical Wnt Signaling Pathway Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Keratinization Formation of the cornified envelope	Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CDH11 homotypic and heterotypic interactions
Drugs			Zinc Zinc acetate
Diseases			Naxos disease and Carvajal syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Anorectal malformation ( 31136621) Lymphocyte count ( 32888494)	Heel bone mineral density ( 28869591 30598549) Major depressive disorder x sex interaction ( 34099189)
Interacting Genes		10 interacting genes: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP IQUB JUP KRT18	55 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HDAC1 HDAC2 HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9
Entrez ID		11187	3728
HPRD ID		05711	01414
Ensembl ID		ENSG00000184363	ENSG00000173801
Uniprot IDs		Q9Y446	A0A0S2Z487 P14923
PDB IDs			3IFQ
Enriched GO Terms of Interacting Partners?		Desmosome Cornified Envelope Desmosome Organization Cell-cell Adhesion Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Anchoring Junction Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Cell-cell Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Homotypic Cell-cell Adhesion Cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Calcium Ion Binding Positive Regulation Of Protein Localization To Cell-cell Junction Regulation Of Muscle Contraction Adherens Junction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Regulation Of Protein Localization To Cell-cell Junction Desmosome Assembly Regulation Of Muscle System Process Regulation Of Blood Circulation Gamma-catenin Binding Extracellular Exosome Cell-cell Junction Assembly Epithelial Cell-cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Intermediate Filament Structural Molecule Activity Regulation Of Biological Quality Maternal Process Involved In Female Pregnancy Response To Progesterone Regulation Of System Process Regulation Of P38MAPK Cascade	Beta-catenin Binding Desmosome Cell Junction Cell-cell Adhesion Gamma-catenin Binding Cell Junction Organization Anchoring Junction Cell Adhesion Cell-cell Junction Organization Adherens Junction Cell-cell Junction Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Junction Assembly Cadherin Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Catenin Complex Cornified Envelope Anatomical Structure Morphogenesis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cell Migration Cell Motility Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Positive Regulation Of Protein Localization Regulation Of Protein Localization To Cell-cell Junction Developmental Process Lateral Plasma Membrane Cell Surface Receptor Signaling Pathway Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Intracellular Signal Transduction Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Apoptotic Process Plasma Membrane Intercalated Disc
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