PKP3 and DSG2

Number of citations of the paper that reports this interaction (PubMedID 12707304)
49

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		PKP3	DSG2
Description		plakophilin 3	desmoglein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Membrane Cell Junction Desmosome Anchoring Junction	Cornified Envelope Cytoplasm Plasma Membrane Cell-cell Junction Cell Surface Intercalated Disc Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Desmosome Extracellular Exosome Anchoring Junction
	Molecular Function	RNA Binding Protein Binding Enzyme Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cadherin Binding Involved In Cell-cell Adhesion	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Desmosome Assembly Regulation Of Cytokine Production Involved In Immune Response Desmosome Organization Regulation Of Translation Cell Adhesion Regulation Of Gene Expression Epithelial Structure Maintenance Positive Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Regulation Of Hair Follicle Development Protein Localization To Plasma Membrane Epithelial Cell-cell Adhesion Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization	Desmosome Organization Purkinje Myocyte Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Epithelial To Mesenchymal Transition Response To Progesterone Negative Regulation Of Apoptotic Process Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Cell Adhesion Maternal Process Involved In Female Pregnancy Mesenchymal To Epithelial Transition Stem Cell Proliferation Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Sprouting Angiogenesis
Pathways		Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Anorectal malformation ( 31136621) Lymphocyte count ( 32888494)	Blood protein levels ( 30072576)
Interacting Genes		10 interacting genes: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP IQUB JUP KRT18	5 interacting genes: DSC1 DSC2 JUP PKP2 PKP3
Entrez ID		11187	1829
HPRD ID		05711	00516
Ensembl ID		ENSG00000184363	ENSG00000046604
Uniprot IDs		Q9Y446	A0AAQ5BGT2 Q14126
PDB IDs			2YQG 5ERD 5J5J 6QNT 6QNU 6SIT 7A7D 7AGF 7AGG 8QJX 8QJY 8QK3
Enriched GO Terms of Interacting Partners?		Desmosome Cornified Envelope Desmosome Organization Cell-cell Adhesion Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Anchoring Junction Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Cell-cell Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Homotypic Cell-cell Adhesion Cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Calcium Ion Binding Positive Regulation Of Protein Localization To Cell-cell Junction Regulation Of Muscle Contraction Adherens Junction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Regulation Of Protein Localization To Cell-cell Junction Desmosome Assembly Regulation Of Muscle System Process Regulation Of Blood Circulation Gamma-catenin Binding Extracellular Exosome Cell-cell Junction Assembly Epithelial Cell-cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Intermediate Filament Structural Molecule Activity Regulation Of Biological Quality Maternal Process Involved In Female Pregnancy Response To Progesterone Regulation Of System Process Regulation Of P38MAPK Cascade	Desmosome Cornified Envelope Desmosome Organization Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Alpha-catenin Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Anchoring Junction Cell-cell Adhesion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Junction Organization Adherens Junction Cell Junction Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Cell Adhesion Regulation Of Action Potential Homotypic Cell-cell Adhesion Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Cell Junction Organization Cell-cell Junction Assembly Epithelial Cell-cell Adhesion Regulation Of Muscle Contraction Protein Localization To Plasma Membrane Regulation Of Heart Contraction Cell-cell Junction Protein Localization To Cell Periphery Regulation Of Muscle System Process Regulation Of Blood Circulation Cell Junction Assembly Protein Localization To Membrane Cadherin Binding Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Gamma-catenin-TCF7L2 Complex Localization Within Membrane Cell Adhesion Molecule Binding Maintenance Of Protein Localization At Cell Tip Regulation Of System Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Desmosome Maintenance Intermediate Filament Catenin-TCF7L2 Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?