LZTS1 and MFAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LZTS1	MFAP1
Description		leucine zipper tumor suppressor 1	microfibril associated protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Cell Projection Dendritic Spine Synapse Glutamatergic Synapse	Microfibril Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex Centrosome U2-type Precatalytic Spliceosome
	Molecular Function	Protein Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Macroautophagy Regulation Of Synaptic Plasticity Regulation Of Dendrite Morphogenesis Regulation Of Postsynapse Assembly	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Circulating myeloperoxidase levels (serum) ( 23620142) Dental caries ( 23064961 23259602) Femur bone mineral density x serum urate levels interaction ( 34046847) Influenza A (H1N1) infection ( 26379185) Interleukin-6 levels ( 33517400) Major depressive disorder (broad) ( 20038947) Persistent hepatitis B virus infection ( 27244555) Preeclampsia ( 23551011) Rheumatoid arthritis ( 30891314) Severe influenza A (H1N1) infection ( 26379185)	Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)
Interacting Genes		100 interacting genes: AGTR1 AMOT AP1M1 BYSL CARD9 CCDC102B CCDC120 CCDC13 CCDC187 CCDC57 CCHCR1 CDC23 CDC25C CDC37 CDC7 CDK1 CEP83 CKS1B COG2 COPB1 CWF19L2 DDX6 DRC4 EEF1G ELOA ENKD1 EXOC8 FAM161A FAM161B FAM50B FAM81B FAM90A1 GARIN1B GOLGA1 GPKOW HMGB2 IDO2 KANK2 KAT5 KAZN KDM1A KIF9 KIFC3 LENG1 LMNB2 LMO1 LMO2 LMO3 LMO4 LNX1 LSM2 MAPK9 MCRS1 METTL21A MFAP1 MID2 MTCL2 NEK6 NTAQ1 PIBF1 PICK1 PLEKHA7 POLR1C POLR3C PPP1R18 PRKAB2 PRPF18 PRPF3 PSMA1 PSPC1 QARS1 RABIF RHPN1 RSPH14 RUNX1T1 SCNM1 SGF29 SPDYC SUFU SYT17 SYT6 SYTL4 TBC1D1 TBC1D7 TCEA2 TSGA10 TSGA10IP TTC9C TXLNA TXLNB TXNDC9 UBASH3A ZGPAT ZMYND19 ZNF250 ZNF3 ZNF35 ZNF417 ZNF572 ZNF587	88 interacting genes: ALKBH8 AMOTL2 AP2M1 BEND7 BICD2 CARD9 CCDC102B CCDC33 CCDC57 CDC14B CDCA7L CEP55 CEP57L1 CEP70 CEP76 COG6 CSNK2A1 DHX38 DHX8 DNTTIP1 DRC4 FAM9B FRA10AC1 FXR1 FXR2 GKAP1 GOLGA2 GOLGA6L9 GPRASP3 GRIPAP1 HMBOX1 HOMER3 HOOK2 HSF2BP HSPB1 IK KATNBL1 KIFC3 KLHL2 KRT40 L3MBTL3 LDOC1 LMNA LMNB2 LZTS1 MAD1L1 MCRS1 MID2 MIPOL1 MTUS2 NDC80 NGDN OGT OLIG3 PAX6 PHC2 PIBF1 PIH1D1 PLEKHF2 SNW1 SSX2IP STAC3 STX11 TADA2A TCP10L TEPSIN TFIP11 THAP1 TLE5 TRAF2 TRIM41 TRIM42 TRIM54 U2AF1 VPS52 YWHAG ZBTB1 ZBTB14 ZBTB8A ZFP1 ZFP41 ZFP64 ZNF398 ZNF41 ZNF558 ZNF620 ZNF71 ZNF76
Entrez ID		11178	4236
HPRD ID		05945	02569
Ensembl ID		ENSG00000061337	ENSG00000140259
Uniprot IDs		Q9Y250	P55081
PDB IDs		8Y1U	5F5S 5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton DNA-binding Transcription Factor Binding Centrosome Centriole Nucleoplasm Cilium Organization Microtubule Cytoskeleton Organization Zonula Adherens Maintenance Cytoplasm	Identical Protein Binding Protein Binding Nucleus Microtubule Binding Cytoskeleton Centrosome Nuclear Pore Localization Zinc Ion Binding Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization TORC1 Complex Assembly MRNA Splicing, Via Spliceosome Protein Kinase C Inhibitor Activity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Catalytic Step 2 Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Spindle Pole Response To Muramyl Dipeptide Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Spliceosomal Complex Microtubule Negative Regulation Of Metabolic Process Intracellular Protein Localization Cytoskeleton Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Macromolecule Metabolic Process Membraneless Organelle Assembly Regulation Of Chromosome Separation Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Negative Regulation Of Chromosome Organization Chromosome Localization Negative Regulation Of Macromolecule Metabolic Process ATP-dependent Activity, Acting On RNA Mitotic Spindle Pole Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Mitotic Nuclear Division Cellular Response To Muramyl Dipeptide Nucleus Organization Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint NSL Complex
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