LZTS1 and CDC25C

Number of citations of the paper that reports this interaction (PMID 17349584)
15

Data Source:
HPRD (in vitro, in vivo)

		LZTS1	CDC25C
Gene Name		leucine zipper, putative tumor suppressor 1	cell division cycle 25C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Postsynaptic Density Apical Plasma Membrane Cell Junction Dendritic Spine Dendritic Shaft Cell Body Postsynaptic Membrane	Nucleus Nucleoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding WW Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Negative Regulation Of Macroautophagy Regulation Of Dendrite Morphogenesis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Spermatogenesis Cell Proliferation Viral Process Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle
Pathways			Cyclin A/B1 associated events during G2/M transition G2/M DNA damage checkpoint G2/M Checkpoints Activation of ATR in response to replication stress Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex G2/M Transition Cell Cycle Checkpoints Mitotic G2-G2/M phases Cyclin B2 mediated events Polo-like kinase mediated events Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (serum) ( 23620142) Dental caries ( 23064961 23259602) Major depressive disorder (broad) ( 20038947) Preeclampsia ( 23551011)
Protein-Protein Interactions		3 interactors: CDC25C CDK1 EEF1G	29 interactors: BRSK1 BRSK2 CCNA2 CCNB1 CDK1 CDK2 CDS1 CHEK1 CHEK2 HRAS LCK LZTS1 MAPK1 MAPK14 MAPK3 MAPK9 MARK3 NEDD4 PCNA PIN1 PKN1 PLK1 PLK3 SRC TP53 YWHAB YWHAH YWHAQ YWHAZ
Entrez ID		11178	995
HPRD ID		05945	01146
Ensembl ID		ENSG00000061337	ENSG00000158402
Uniprot IDs		Q9Y250	P30307
PDB IDs			3BZI 3OP3
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Pronuclear Fusion Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Mitotic Nuclear Division Regulation Of Schwann Cell Differentiation Regulation Of Mitotic Cell Cycle Cell Division Protein Localization To Kinetochore Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Ventricular Cardiac Muscle Cell Development Mitotic Cell Cycle Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Sexual Reproduction Cellular Macromolecule Biosynthetic Process Ventricular Cardiac Muscle Cell Differentiation Protein Localization To Chromosome Positive Regulation Of Cardiac Muscle Cell Proliferation Macromolecule Biosynthetic Process G2 DNA Damage Checkpoint Mitotic Nuclear Envelope Disassembly Regulation Of Cell Cycle Positive Regulation Of Heart Growth Histone Phosphorylation Nuclear Envelope Disassembly Regulation Of Cardiac Muscle Cell Proliferation Reproduction Cell Cycle Process DNA Metabolic Process Regulation Of Protein Phosphorylation Peptidyl-threonine Phosphorylation Chromosome Condensation Positive Regulation Of Organ Growth Response To Amine Cellular Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Activity Centrosome Cycle Response To Cadmium Ion Regulation Of Heart Growth Toll-like Receptor TLR6:TLR2 Signaling Pathway	Cellular Response To Stress Cell Cycle Phosphorylation Response To Stress Cell Cycle Checkpoint Apoptotic Process G2/M Transition Of Mitotic Cell Cycle Programmed Cell Death Cell Death Death Protein Phosphorylation Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Transport Negative Regulation Of Mitotic Cell Cycle Ras Protein Signal Transduction Phosphate-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Regulation Of Protein Phosphorylation Cellular Response To Stimulus Positive Regulation Of Phosphorylation Mitotic Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Mitotic Cell Cycle Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Cell Aging Regulation Of Cellular Localization Regulation Of Phosphorylation Regulation Of Cellular Component Organization Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Cellular Protein Modification Process
Tagcloud ?		acquisition allow cap1 castration cdc25c chek1 chemoresistance develops differentially docetaxel focused igr killed kinases largely microarray mitotic nsc663284 overcome parental partner plk1 prostate resistance resistant signature sirna subset targets	acetyltransferase acetyltransferases aiding ancient assembled box caf ccaat collagen disrupted facilitating gcn5 heterodimers histocompatibility lipase nf pivotal possess r2 reductase ribonucleotide transactivation transfections ubiquitous y ya yb yc
Tagcloud (Difference) ?		acquisition allow cap1 castration chek1 chemoresistance develops differentially docetaxel focused igr killed kinases largely microarray mitotic nsc663284 overcome parental partner plk1 prostate resistance resistant signature sirna subset targets	acetyltransferase acetyltransferases aiding ancient assembled box caf ccaat collagen disrupted facilitating gcn5 heterodimers histocompatibility lipase nf pivotal possess r2 reductase ribonucleotide transactivation transfections ubiquitous y ya yb yc
Tagcloud (Intersection) ?		cdc25c