RAB17 and S100A8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RAB17	S100A8
Gene Name		RAB17, member RAS oncogene family	S100 calcium binding protein A8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Early Endosome Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Dendrite Melanosome Neuronal Cell Body Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding
	Biological Process	Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Intracellular Protein Transport Regulation Of Endocytosis Establishment Of Melanosome Localization Melanosome Transport Endocytic Recycling Rab Protein Signal Transduction Cilium Assembly Transcytosis Filopodium Assembly Regulation Of Dendrite Development Regulation Of Filopodium Assembly Regulation Of Synapse Assembly	Cytokine Production Leukocyte Migration Involved In Inflammatory Response Acute Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Zinc Ion Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Response To Lipopolysaccharide Chemokine Production Wound Healing Defense Response To Bacterium Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: ACVR1 C11orf49 FAM9B MAGEA1 NUDT3 RAB7A RABAC1 S100A8 SMURF2	18 interactors: APP C14orf1 CDKN1A CEACAM3 CHGB GDF9 IGSF21 KLC2 LRIF1 NCF2 PDCD11 PPIA PRMT1 RAB17 S100A9 TP53 TUBA4A UNC119
Entrez ID		64284	6279
HPRD ID		11468	00471
Ensembl ID		ENSG00000124839	ENSG00000143546
Uniprot IDs		Q6PJZ0 Q9H0T7	P05109
PDB IDs			1MR8 1XK4 4GGF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Acute Inflammatory Response BMP Signaling Pathway Regulation Of Signaling Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Epidermal Growth Factor Catabolic Process Endocardial Cushion Cell Fate Commitment Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Catabolic Process Neutrophil Aggregation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Phagosome-lysosome Fusion Sequestering Of Zinc Ion Phagosome Acidification Mitral Valve Morphogenesis Cardiac Muscle Cell Fate Commitment Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mitral Valve Development Ubiquitin-dependent SMAD Protein Catabolic Process Protein To Membrane Docking Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Activin Receptor Signaling Pathway Atrial Septum Primum Morphogenesis Chemokine Production Endocardial Cell Differentiation Sequestering Of Metal Ion Positive Regulation Of Signal Transduction Positive Regulation Of Secretion Septum Primum Development Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Pathway-restricted SMAD Protein Phosphorylation Chronic Inflammatory Response Phagolysosome Assembly Protein Localization To Lysosome Cellular Zinc Ion Homeostasis Regulation Of Autophagic Vacuole Assembly Zinc Ion Homeostasis Leukocyte Migration Involved In Inflammatory Response Muscle Cell Fate Commitment Inflammatory Response Pharyngeal System Development Regulation Of Vacuole Organization Endocardium Development	Blood Coagulation Hemostasis Platelet Degranulation Immune System Process Stress-induced Premature Senescence Regulation Of Body Fluid Levels Wound Healing Regulation Of Growth Mitotic Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Response To Wounding Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Immune Response Negative Regulation Of Cell Growth Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Cellular Senescence Response To Hyperoxia Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Positive Regulation Of Cell Cycle Process Regulation Of Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Cycle Phase Transition Response To Stimulus Response To Abiotic Stimulus Positive Regulation Of Programmed Cell Death Axon Cargo Transport Negative Regulation Of Growth Response To Stress Positive Regulation Of Cell Death Response To External Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Positive Regulation Of Neuron Apoptotic Process Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To UV Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Clathrin-mediated Endocytosis Uncoating Of Virus Mitotic Cell Cycle Process
Tagcloud ?		accessibility acclimation acetyl altogether catalyze cold deacetylases deacetylation demethylation drought hdacs histones hyperacetylation hypoacetylated ice1 maize methylated micrococcal mnase nuclease repressor responding stresses trichostatin tsa zmcor413 zmdbf1 zmdreb1 zmice1	a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac
Tagcloud (Difference) ?		accessibility acclimation acetyl altogether catalyze cold deacetylases deacetylation demethylation drought hdacs histones hyperacetylation hypoacetylated ice1 maize methylated micrococcal mnase nuclease repressor responding stresses trichostatin tsa zmcor413 zmdbf1 zmdreb1 zmice1	a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac
Tagcloud (Intersection) ?