ACACA and TRIB3

Number of citations of the paper that reports this interaction (PubMedID 34128473)
49

Data Source:
BioGRID (pull down)

		ACACA	TRIB3
Description		acetyl-CoA carboxylase alpha	tribbles pseudokinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding Metal Ion Binding	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity Ubiquitin Ligase Activator Activity
	Biological Process	Tissue Homeostasis Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Lipid Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Homotetramerization Lipid Homeostasis Cellular Response To Prostaglandin E Stimulus Malonyl-CoA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Autophagy Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways		ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine shuttle Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis	PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Biotin
Diseases
GWAS		Daytime nap ( 33568662) Ovarian cancer ( 23535730)	Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)
Interacting Genes		15 interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 NEIL3 PRKAA1 PRKAA2 PRKAB1 PRKAG1 TRIB1 TRIB2 TRIB3	100 interacting genes: ACACA AKAP8L AKT1 AKT2 APOBEC3A APOBEC3C APP ARMC7 ATF4 BAG3 BCL6 BFSP2 BMPR2 C21orf58 C22orf39 CBX8 CHAF1A CLCNKA COPS6 CTAG1A CTAG1B DDIT3 DPPA3 DTX2 EEF1G EFEMP2 EPHB6 EXOSC5 FAAP20 FAM161A FAM90A1 FBXO7 GDF9 GIT1 GLIS3 GPATCH2L GRB2 HAT1 HDAC4 HLA-B HNRNPF HOXB5 HOXC8 IL16 INCA1 INO80B IRX6 KANK2 KAT5 KLHL38 KRT26 LENG1 LMO2 LMO3 MDFI MDM2 MISP MYC OIP5 OSTF1 PADI4 PARD6B PCSK5 PITX2 PKNOX2 PML PPP1R26 PRKAB2 PRMT5 PRR19 PSMA3 RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SAMD11 SAXO1 SAXO4 SCNM1 SETDB1 SHFL SNRPC SPAG8 SPG21 SUOX TCF19 TEKT3 TEKT4 TLE5 TRIM55 TRIM63 TTC23 TWIST1 UBTD2 USP20 UTP23 ZNF417 ZNF587
Entrez ID		31	57761
HPRD ID		01938	09836
Ensembl ID		ENSG00000278540	ENSG00000101255
Uniprot IDs		Q13085 Q7Z5W8	B4DMM9 J3KR25 Q96RU7
PDB IDs		2YL2 3COJ 4ASI 6G2D 6G2H 6G2I 8XKZ 8XL0 8XL1 8XL2
Enriched GO Terms of Interacting Partners?		Nucleotide-activated Protein Kinase Complex Ubiquitin-protein Transferase Regulator Activity AMP-activated Protein Kinase Activity Fatty Acid Biosynthetic Process Mitogen-activated Protein Kinase Kinase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Small Molecule Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Phosphorus Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Lipid Metabolic Process Carboxylic Acid Biosynthetic Process Protein Kinase CK2 Complex Protein Kinase Activity Protein Localization To Lipid Droplet Fatty Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Catabolic Process Protein Kinase Inhibitor Activity Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Translational Initiation Negative Regulation Of Tubulin Deacetylation CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Cellular Response To Glucose Starvation Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Tubulin Deacetylation Regulation Of Glycolytic Process Lipid Droplet Disassembly Regulation Of Proteolysis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Lipid Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MAP Kinase Activity Cellular Response To Stress Negative Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Phosphatidylethanolamine Biosynthetic Process Small Molecule Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Protein Deacetylation	Nucleus Protein Binding Negative Regulation Of Gene Expression DNA-binding Transcription Factor Binding Identical Protein Binding Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Epigenetic Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Gene Expression Axonemal A Tubule Inner Sheath Negative Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytoplasm Innate Immune Response PERK-mediated Unfolded Protein Response CHOP-ATF4 Complex Axonemal Microtubule DNA Deamination Chromatin RNA Metabolic Process Response To Radiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Signal Transduction By P53 Class Mediator Lewy Body Core Regulation Of Apoptotic Signaling Pathway Response To Growth Factor Response To Light Stimulus Defense Response To Symbiont Regulation Of Fatty Acid Beta-oxidation Response To Interleukin-1 Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Translational Initiation
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