PRAG1

Description		PEAK1 related, kinase-activating pseudokinase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Anchoring Junction
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Shape Regulation Of Notch Signaling Pathway Negative Regulation Of Neuron Projection Development Cell Migration Positive Regulation Of Rho Protein Signal Transduction Regulation Of Cell Motility
Pathways		RND2 GTPase cycle
Drugs
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Processed meat consumption ( 32066663) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid stimulating hormone levels ( 32769997) TPE interval (resting) ( 32386560)
Interacting Genes		3 interacting genes: CHGB PSAP UBE3A
Entrez ID		157285
HPRD ID		19497
Ensembl ID		ENSG00000275342
Uniprot IDs		Q86YV5
PDB IDs		5VE6 8DGN
Enriched GO Terms of Interacting Partners?		Prostate Gland Growth Organ Growth Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Sperm Entry Positive Regulation Of Golgi Lumen Acidification Ganglioside GT1b Binding Ganglioside GM1 Binding Regulation Of Golgi Lumen Acidification Positive Regulation Of Cellular PH Reduction Positive Regulation Of Protein Localization To Lysosome Developmental Growth Glycolipid Transport Epithelial Cell Differentiation Involved In Prostate Gland Development Progesterone Receptor Signaling Pathway Ceramide Transport Androgen Receptor Signaling Pathway Postsynaptic Cytosol
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