GTF2A1L and HOXC9

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		GTF2A1L	HOXC9
Description		general transcription factor IIA subunit 1 like	homeobox C9
Image		No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Transcription Factor TFIIA Complex Cytoplasm	Chromatin Nucleus Nucleoplasm Aggresome Transcription Repressor Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription Cognition	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Negative Regulation Of Cell Cycle Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Hepcidin/ferritin ratio ( 27846281) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Joint mobility (Beighton score) ( 27182965) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 21151128)	A body shape index ( 34021172) Heel bone mineral density ( 30598549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		25 interacting genes: ASCL3 ATF4 CEBPE CSNK2A1 CSNK2A2 EMX1 EMX2 GAB1 GTF2A2 HMG20A HOXA5 HOXC11 HOXC9 ID3 MAFF MAFG NKX2-3 PAX9 RBFOX2 SIX6 SUB1 TBP TLX2 TLX3 ZBTB3	29 interacting genes: CBX6 CYSRT1 ELAVL2 GMNN GTF2A1L HOXC13 HOXD1 HOXD9 IRF9 KRTAP6-2 LPXN MAGED1 MSX2 NFKBID NMI PAX6 PAX8 PBX2 PCGF2 POLR2D POLR3D POU2AF1 POU2F1 SPMIP9 TLE5 UFSP1 ZFP36 ZMYND12 ZNF384
Entrez ID		11036	3225
HPRD ID		05640	00857
Ensembl ID		ENSG00000242441	ENSG00000180806
Uniprot IDs		Q9UNN4	P31274
PDB IDs			2LP0 2MSY
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein Kinase CK2 Complex System Development Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Transcription Factor TFIIA Complex DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cerebral Cortex Regionalization Regionalization RNA Polymerase II General Transcription Initiation Factor Binding Central Nervous System Development Nucleoplasm Anterior/posterior Pattern Specification RNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Neuron Differentiation Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Embryonic Skeletal System Morphogenesis	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regionalization Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Pattern Specification Process Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Anterior/posterior Pattern Specification DNA-binding Transcription Factor Activity Chromatin Binding Animal Organ Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Embryonic Morphogenesis Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Metabolic Process Embryonic Skeletal System Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal System Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Embryonic Limb Morphogenesis PRC1 Complex Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process
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