GTF2A1L and SIX6

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		GTF2A1L	SIX6
Description		general transcription factor IIA subunit 1 like	SIX homeobox 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Transcription Factor TFIIA Complex Cytoplasm	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription Cognition	Eye Development Regulation Of Transcription By RNA Polymerase II Visual Perception Animal Organ Morphogenesis
Pathways
Drugs
Diseases			Anophthalmia and microphthalmia (A/M)
GWAS		Adult body size ( 32376654) Hepcidin/ferritin ratio ( 27846281) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Joint mobility (Beighton score) ( 27182965) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 21151128)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 22419738 33627673 29891935 29452408 22570617 25173105) Gut microbiota (bacterial taxa) ( 27723756) Height ( 20881960 25429064) Medication use (antiglaucoma preparations and miotics) ( 31015401) Menarche (age at onset) ( 25231870) Optic cup area ( 28073927 25631615 31798171) Optic disc area ( 25631615 28073927 31798171) Refractive error ( 23396134 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio ( 28073927 31798171 25241763)
Interacting Genes		25 interacting genes: ASCL3 ATF4 CEBPE CSNK2A1 CSNK2A2 EMX1 EMX2 GAB1 GTF2A2 HMG20A HOXA5 HOXC11 HOXC9 ID3 MAFF MAFG NKX2-3 PAX9 RBFOX2 SIX6 SUB1 TBP TLX2 TLX3 ZBTB3	3 interacting genes: GTF2A1L TLE1 TLE5
Entrez ID		11036	4990
HPRD ID		05640	07557
Ensembl ID		ENSG00000242441	ENSG00000184302
Uniprot IDs		Q9UNN4	O95475 Q6P051
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein Kinase CK2 Complex System Development Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Transcription Factor TFIIA Complex DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cerebral Cortex Regionalization Regionalization RNA Polymerase II General Transcription Initiation Factor Binding Central Nervous System Development Nucleoplasm Anterior/posterior Pattern Specification RNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Neuron Differentiation Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Embryonic Skeletal System Morphogenesis	Regulation Of Anoikis Transcription Corepressor Activity Positive Regulation Of Anoikis Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of B Cell Receptor Signaling Pathway Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Translation In Response To Stress Transcription Factor TFIIA Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Glial Cell Proliferation Regulation Of B Cell Receptor Signaling Pathway Translation Regulator Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Keratinocyte Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine Kinase Binding Beta-catenin-TCF Complex Negative Regulation Of Anoikis Regulation Of PERK-mediated Unfolded Protein Response Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Epidermal Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?