GTF2A1L and EMX2

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		GTF2A1L	EMX2
Name		general transcription factor IIA subunit 1 like	empty spiracles homeobox 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Transcription Factor TFIIA Complex Cytoplasm	Chromatin Nucleus Axon Cell Projection
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription Cognition	Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Response To Xenobiotic Stimulus Anterior/posterior Pattern Specification Regulation Of Gene Expression Dentate Gyrus Development Cerebral Cortex Regionalization Cell Proliferation In Forebrain Forebrain Cell Migration Cerebral Cortex Development Neuron Differentiation Forebrain Development Ureter Morphogenesis Stereocilium Bundle Organization
Pathways		None	Formation of the nephric duct
GWAS		Adult body size ( 32376654 ) Hepcidin/ferritin ratio ( 27846281 ) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597 ) Joint mobility (Beighton score) ( 27182965 ) Laterality in neovascular age-related macular degeneration ( 28775256 ) Polycystic ovary syndrome ( 21151128 )	Airflow obstruction ( 22837378 ) Celiac disease ( 23936387 ) Chronotype ( 30696823 ) Double-edged eyelids ( 29895819 ) Early cardiac repolarization ( 22683750 ) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828 ) Liver fibrosis (total hepatic collagen content) ( 32953199 ) Low tan response ( 29739929 ) Neuroticism ( 29255261 ) Obesity-related traits ( 23251661 ) Ovarian disease with few adhesions ( 28333195 ) Photic sneeze reflex ( 27182965 ) Pulmonary function in asthmatics ( 23541324 ) Response to quetiapine in schizophrenia ( 29503163 ) Serum uric acid levels ( 29403010 30993211 ) Skin pigmentation ( 30664655 ) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655 ) Urate levels ( 31578528 )
Interacting Genes		25 interacting genes: ASCL3 ATF4 CEBPE CSNK2A1 CSNK2A2 EMX1 EMX2 GAB1 GTF2A2 HMG20A HOXA5 HOXC11 HOXC9 ID3 MAFF MAFG NKX2-3 PAX9 RBFOX2 SIX6 SUB1 TBP TLX2 TLX3 ZBTB3	5 interacting genes: EIF4E GTF2A1L MEIS1 OTUD6A TLE2
Entrez ID		11036	2018
HPRD ID		05640	02495
Ensembl ID		ENSG00000242441	ENSG00000170370
Uniprot IDs		Q9UNN4	Q04743
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein Kinase CK2 Complex System Development Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Transcription Factor TFIIA Complex DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cerebral Cortex Regionalization Regionalization RNA Polymerase II General Transcription Initiation Factor Binding Central Nervous System Development Nucleoplasm Anterior/posterior Pattern Specification RNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Neuron Differentiation Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Embryonic Skeletal System Morphogenesis	Eukaryotic Initiation Factor 4G Binding MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Neuron Differentiation Regulation Of Translation At Postsynapse Negative Regulation Of Neuron Differentiation Transcription Factor TFIIA Complex Protein K33-linked Deubiquitination Protein K27-linked Deubiquitination Protein K29-linked Deubiquitination Transcription Regulator Complex Cell Growth Involved In Cardiac Muscle Cell Development