CLP1 and HCFC1

Number of citations of the paper that reports this interaction (PMID 11384994)
6

Data Source:
BioGRID (two hybrid)

		CLP1	HCFC1
Gene Name		cleavage and polyadenylation factor I subunit 1	host cell factor C1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytoplasm MRNA Cleavage Factor Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Mitochondrion Membrane Neuronal Cell Body Set1C/COMPASS Complex SAGA-type Complex MLL5-L Complex MLL1 Complex
	Molecular Function	ATP Binding ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polydeoxyribonucleotide Kinase Activity ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Identical Protein Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Splicing Gene Expression Phosphorylation Cerebellar Cortex Development Targeting Of MRNA For Destruction Involved In RNA Interference MRNA 3'-end Processing SiRNA Loading Onto RISC Involved In RNA Interference	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Cell Cycle Positive Regulation Of Gene Expression Release From Viral Latency Regulation Of Protein Complex Assembly Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs mRNA 3'-end processing	Chromatin modifying enzymes Organelle biogenesis and maintenance Chromatin organization Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Mitochondrial biogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP CPSF3 CREB3 HCFC1 NUDT21	31 interactors: ASF1B CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIN3A SP1 TAF9 THAP11 THAP7 YY1 ZBTB17
Entrez ID		10978	3054
HPRD ID		16382	02061
Ensembl ID		ENSG00000172409	ENSG00000172534
Uniprot IDs		Q92989	P51610
PDB IDs			4GO6
Enriched GO Terms of Interacting Partners?		MRNA Polyadenylation RNA Polyadenylation Release From Viral Latency MRNA 3'-end Processing RNA 3'-end Processing Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription RNA Metabolic Process MRNA Processing Gene Expression DNA-templated Transcription, Termination MRNA Metabolic Process RNA Processing Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Synaptic Growth At Neuromuscular Junction Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Collateral Sprouting Axon Midline Choice Point Recognition Histone MRNA 3'-end Processing Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Deacetylase Activity Axon Choice Point Recognition Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Neuron Remodeling Establishment Of Viral Latency RNA Splicing Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Regulation Of Monocyte Chemotaxis Histone H4-K16 Acetylation Positive Regulation Of Defense Response To Virus By Host	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Cellular Process Rhythmic Process Negative Regulation Of Cellular Metabolic Process Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Metabolic Process Cellular Response To Stress Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Initiation Response To Oxidative Stress Cellular Response To Organic Substance Circadian Rhythm Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Regulation Of Cell Proliferation
Tagcloud ?		aberrant axonal dead degeneration denervation determining elusive fatal fragments inactivation junctions k link mechanistic mechanistically motor nerves neuromuscular neuron paralysis progressive rescue rescues respiratory sensitize trna trp53 uncover weakness	capd3 capg2 condensin conjunction demethylase demethylases dismissal e2f1 ever expanding h3k27me2 h3k4me2 h3k9me1 h4k20me1 intimate jmjc jumonji ncapd3 ncapg2 phd phf8 prophase recognizing removing seq set1a setd1a smc
Tagcloud (Difference) ?		aberrant axonal dead degeneration denervation determining elusive fatal fragments inactivation junctions k link mechanistic mechanistically motor nerves neuromuscular neuron paralysis progressive rescue rescues respiratory sensitize trna trp53 uncover weakness	capd3 capg2 condensin conjunction demethylase demethylases dismissal e2f1 ever expanding h3k27me2 h3k4me2 h3k9me1 h4k20me1 intimate jmjc jumonji ncapd3 ncapg2 phd phf8 prophase recognizing removing seq set1a setd1a smc
Tagcloud (Intersection) ?