CLP1 and CPSF3

Number of citations of the paper that reports this interaction (PMID 11060040)
61

Data Source:
HPRD (in vivo, in vitro)

		CLP1	CPSF3
Gene Name		cleavage and polyadenylation factor I subunit 1	cleavage and polyadenylation specific factor 3, 73kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytoplasm MRNA Cleavage Factor Complex	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Ribonucleoprotein Complex
	Molecular Function	ATP Binding ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polydeoxyribonucleotide Kinase Activity ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity	RNA Binding Endoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Splicing Gene Expression Phosphorylation Cerebellar Cortex Development Targeting Of MRNA For Destruction Involved In RNA Interference MRNA 3'-end Processing SiRNA Loading Onto RISC Involved In RNA Interference	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage Histone MRNA 3'-end Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs mRNA 3'-end processing	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Transport of Mature mRNA Derived from an Intronless Transcript RNA Polymerase II Transcription Transport of Mature mRNAs Derived from Intronless Transcripts Cleavage of Growing Transcript in the Termination Region mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Intronless Pre-mRNAs Processing of Capped Intronless Pre-mRNA Transport of Mature Transcript to Cytoplasm RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP CPSF3 CREB3 HCFC1 NUDT21	4 interactors: CLP1 PAPOLA POLR2A YWHAG
Entrez ID		10978	51692
HPRD ID		16382	05825
Ensembl ID		ENSG00000172409	ENSG00000119203
Uniprot IDs		Q92989	G5E9W3 Q9UKF6
PDB IDs			2I7T 2I7V
Enriched GO Terms of Interacting Partners?		MRNA Polyadenylation RNA Polyadenylation Release From Viral Latency MRNA 3'-end Processing RNA 3'-end Processing Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription RNA Metabolic Process MRNA Processing Gene Expression DNA-templated Transcription, Termination MRNA Metabolic Process RNA Processing Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Synaptic Growth At Neuromuscular Junction Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Collateral Sprouting Axon Midline Choice Point Recognition Histone MRNA 3'-end Processing Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Deacetylase Activity Axon Choice Point Recognition Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Neuron Remodeling Establishment Of Viral Latency RNA Splicing Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Regulation Of Monocyte Chemotaxis Histone H4-K16 Acetylation Positive Regulation Of Defense Response To Virus By Host	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Polyadenylation RNA Splicing Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Metabolic Process RNA Processing DNA-templated Transcription, Termination MRNA 3'-end Processing RNA 3'-end Processing Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Serine/threonine Kinase Activity SiRNA Loading Onto RISC Involved In RNA Interference Transcription, RNA-templated Carbohydrate Mediated Signaling Targeting Of MRNA For Destruction Involved In RNA Interference Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation NcRNA Metabolic Process RNA Interference Phagocytosis, Recognition MRNA Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Transcription, DNA-templated Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway RNA Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity MRNA Polyadenylation 7-methylguanosine MRNA Capping PiRNA Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of RNA Splicing 7-methylguanosine RNA Capping Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Posttranscriptional Gene Silencing Negative Regulation Of Cellular Protein Metabolic Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Negative Regulation Of Protein Metabolic Process RNA Metabolic Process Positive Regulation Of Mitochondrion Organization Transcription Elongation From RNA Polymerase II Promoter Gene Silencing By RNA
Tagcloud ?		aberrant axonal dead degeneration denervation determining elusive fatal fragments inactivation junctions k link mechanistic mechanistically motor nerves neuromuscular neuron paralysis progressive rescue rescues respiratory sensitize trna trp53 uncover weakness
Tagcloud (Difference) ?		aberrant axonal dead degeneration denervation determining elusive fatal fragments inactivation junctions k link mechanistic mechanistically motor nerves neuromuscular neuron paralysis progressive rescue rescues respiratory sensitize trna trp53 uncover weakness
Tagcloud (Intersection) ?