HCFC1 and PDCD2

Number of citations of the paper that reports this interaction (PubMedID 12149646)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		HCFC1	PDCD2
Description		host cell factor C1	programmed cell death 2
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Membrane Protein-containing Complex Histone Methyltransferase Complex Neuronal Cell Body NSL Complex MLL1/2 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Cytoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Protein-macromolecule Adaptor Activity Chromatin DNA Binding Identical Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression Release From Viral Latency Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization	Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Celiac disease ( 22057235) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26502338)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
Interacting Genes		34 interacting genes: ASF1B CEBPA CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 FOXK2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIAH1 SIN3A SP1 SUMO2 TAF9 THAP11 THAP7 ZBTB17	7 interacting genes: ERRFI1 HCFC1 LSM8 NCOR1 NFKBIB PRKN TBC1D21
Entrez ID		3054	5134
HPRD ID		02061	02922
Ensembl ID		ENSG00000172534	ENSG00000071994
Uniprot IDs		A6NEM2 P51610	A0A087WYJ3 F5H4V9 J3QK82 Q16342
PDB IDs		4GO6 4N39 4N3A 4N3B 4N3C 5LWV 6MA1 6MA2 6MA3 6MA4 6MA5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Chromatin Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Transcription Regulator Complex Integrated Stress Response Signaling Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Circadian Regulation Of Gene Expression	Negative Regulation Of MAPK Cascade Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of JNK Cascade Regulation Of Phosphorus Metabolic Process Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of ATP Metabolic Process Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Response To Glucocorticoid Negative Regulation Of Intralumenal Vesicle Formation Negative Regulation Of Kinase Activity Regulation Of Purine Nucleotide Metabolic Process Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Kinase Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SH3 Domain Binding Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Histone Deacetylase Binding Response To Curcumin Negative Regulation Of Phosphorylation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of JNK Cascade Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Response To Corticosteroid Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Regulation Of MAPK Cascade Negative Regulation Of Catalytic Activity Release From Viral Latency Type 2 Mitophagy Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Regulation Of Synaptic Vesicle Transport Sperm Mitochondrial Sheath Assembly Lewy Body Regulation Of Spontaneous Synaptic Transmission Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake
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