CLP1 and PCMT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLP1	PCMT1
Description		cleavage factor polyribonucleotide kinase subunit 1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
Image
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytosol MRNA Cleavage Factor Complex	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity Cadherin Binding
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Processing MRNA Processing TRNA Processing Cerebellar Cortex Development MRNA 3'-end Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage	Protein Methylation Protein Repair Methylation
Pathways		tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Protein repair
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Neuroticism ( 29255261) Schizophrenia ( 25056061 29483656)	Brain morphology (MOSTest) ( 32665545) Serum metabolite levels ( 33031748) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: APP CEP164 CPSF3 CREB3 DAGLB FGF16 FTO HCFC1 MEOX2 MESD NUDT21 PCMT1 PRR3 PSMB5 SNF8 YJU2B	15 interacting genes: AGTR1 APOA1 APOE CCR2 CEBPA CHD3 CLP1 CREBBP CYSLTR2 DLG4 IQCB1 RPIA TAAR1 VKORC1 WEE2-AS1
Entrez ID		10978	5110
HPRD ID		16382	08908
Ensembl ID		ENSG00000172409	ENSG00000120265
Uniprot IDs		Q92989	A0A384MDK7 A0A3F2YNX8 B7Z972 F6S8N6 P22061
PDB IDs		8HMY 8HMZ	1I1N 1KR5
Enriched GO Terms of Interacting Partners?		Release From Viral Latency Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Cleavage And Polyadenylation Specificity Factor Complex Positive Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Toll Signaling Pathway Chromatin Binding Regulation Of Monocyte Chemotaxis Positive Regulation Of Deacetylase Activity MRNA 3'-end Processing Positive Regulation Of Pro-B Cell Differentiation RNA Repair TRNA Demethylase Activity	Protein-containing Complex Remodeling Positive Regulation Of Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Phospholipid Efflux Positive Regulation Of Steroid Metabolic Process AMPA Glutamate Receptor Clustering Regulation Of Cholesterol Metabolic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Regulation Of Inflammatory Response Lipoprotein Particle Binding G Protein-coupled Receptor Signaling Pathway High-density Lipoprotein Particle Assembly Energy Homeostasis Regulation Of Defense Response Intracellular Signaling Cassette Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Neurotransmitter-gated Ion Channel Clustering Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Locomotory Exploration Behavior Low-density Lipoprotein Particle Remodeling Protein-containing Complex Organization Regulation Of Steroid Metabolic Process Reverse Cholesterol Transport Endocytic Vesicle Lumen Cholesterol Metabolic Process Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Sterol Metabolic Process High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Regulation Of Lipid Transport Protein-lipid Complex Assembly Positive Regulation Of Lipid Metabolic Process G Protein-coupled Receptor Activity Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Positive Regulation Of Cytosolic Calcium Ion Concentration Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Metabolic Process Lipid Homeostasis Exploration Behavior
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