HCFC1 and GABPA

Number of citations of the paper that reports this interaction (PubMedID 10675337)
54

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		HCFC1	GABPA
Description		host cell factor C1	GA binding protein transcription factor subunit alpha
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Membrane Protein-containing Complex Histone Methyltransferase Complex Neuronal Cell Body NSL Complex MLL1/2 Complex Set1C/COMPASS Complex MLL1 Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Protein-macromolecule Adaptor Activity Chromatin DNA Binding Identical Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression Release From Viral Latency Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Blastocyst Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases Formation of WDR5-containing histone-modifying complexes	Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Celiac disease ( 22057235) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26502338)	Glaucoma (primary open-angle) ( 33627673) Gout (normal type) ( 32238385) Nicotine dependence symptom count ( 25555482)
Interacting Genes		34 interacting genes: ASF1B CEBPA CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 FOXK2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIAH1 SIN3A SP1 SUMO2 TAF9 THAP11 THAP7 ZBTB17	14 interacting genes: APP ATF1 CEBPA CREBBP EP300 GABPB1 HCFC1 MED1 OGT PINX1 SP1 SP3 STK16 ZC2HC1B
Entrez ID		3054	2551
HPRD ID		02061	11793
Ensembl ID		ENSG00000172534	ENSG00000154727
Uniprot IDs		A6NEM2 P51610	A8IE48 Q06546 Q8IYS3
PDB IDs		4GO6 4N39 4N3A 4N3B 4N3C 5LWV 6MA1 6MA2 6MA3 6MA4 6MA5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Chromatin Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Transcription Regulator Complex Integrated Stress Response Signaling Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Circadian Regulation Of Gene Expression	Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-DNA Complex Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hemopoiesis DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Placenta Development Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Protein Localization To Nucleus Transcription Coactivator Binding Regulation Of Glycolytic Process Chromatin Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Defense Response Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of ATP Metabolic Process STAT Family Protein Binding NSL Complex
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